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| Clinical Study on Duloxetine and Duloxetine Combined With Aripiprazole in Treatment of Depression |
| Wang Chunfang1, Deng Fangyuan2, Duan Na1 |
1. Clinical Psychology,Zhumadian Mental Hospital,Zhumadian 463000,China;
2. Emergency Department,Zhumadian Mental Hospital,Zhumadian 463000,China |
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Abstract Objective To observe clinical curative effect of duloxetine and duloxetine combined with aripiprazole on depression.Methods 78 depression patients who were admitted to the hospital were enrolled.They were divided into two groups by random number table method,39 cases in each group.The control group was given duloxetine,while observation group was given duloxetine combined with aripiprazole.After 8 weeks of observation,curative effect was compared between the two groups.The score of Hamilton Depression Scale（HAMD）,curative effect,scores of Pittsburgh Sleep Quality Index（PSQI）,Quality of Life（QOL） and treatment emergent symptom scale（TESS） after treatment were compared between the two groups.Results On the 2nd,4th,6th and 8th week after treatment,HAMD scores of observation group were higher than those of control group（P<0.05）.After treatment,efficiency rate of observation group was higher than that of control group（P<0.05）.PSQI of observation group was significantly lower than that of control group,while QOL was significantly higher than that of control group（P<0.05）.There was no significant difference in TESS score between the two groups（P>0.05）.Conclusion The curative effect of duloxetine combined with aripiprazole is better on depression,which can effectively improve their sleep and quality of life,without significant adverse reactions.
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Received: 20 May 2020
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[1] Shaik S,Rajkumar RP,Menon V,et al.Gender,life events,and depression:An exploratory study[J].Indian Journal of Psychological Medicine,2017,39(3):330-335.
[2] 汪卫华,隋云川,刘丽,等.抑郁症患者单次小剂量氯胺酮的疗效及血清瘦素和5-HT水平变化[J].中国心理卫生杂志,2018,32(12):977-981.
[3] 李季,杨靖,刘安昌.度洛西汀与文拉法辛治疗老年抑郁症的疗效及对血清脑源性神经生长因子、5-羟色胺、去甲肾上腺素的影响[J].中国老年学杂志,2018,38(24):6012-6014.
[4] 卢静,冯小荣,黄媛,等.老年人抗抑郁药临床应用的研究进展[J].华西药学杂志,2018,33(4):435-439.
[5] 杜扬,邱昌建,李诗逸.度洛西汀与舍曲林治疗中国老年抑郁症患者的疗效与安全性的Meta分析[J].中国新药与临床杂志,2018,37(6):351-357.
[6] 卢葭,陈亮,谢鹏.阿立哌唑增效治疗难治性抑郁症的有效性和安全性的系统评价[J].中国医院药学杂志,2013,33(8):627-632.
[7] 李丛梅,董丽华,王桂红.阿立哌唑口崩片联合度洛西汀治疗老年女性抑郁症伴焦虑患者的疗效及安全性评价[J].中国地方病防治杂志,2017,21(1):86.
[8] 杨洋,沈慧,张捷.抑郁症残留症状的临床研究进展[J].中华中医药杂志,2018,33(3):1024-1026.
[9] 汪卫华,隋云川,刘丽,等.抑郁症患者单次小剂量氯胺酮的疗效及血清瘦素和5-HT水平变化[J].中国心理卫生杂志,2018,32(12):977-981. |
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2021, Vol. 41 
