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| Efficacy of Ulcer Decoction Combined With Rabeprazole in the Treatment of hp-Associated Duodenal Ulcer and Its Effect on Serum NF- B and TNF-in Patients |
| Li Jing |
| Department of Western Medicine,Nanyang First People's Hospital,Nanyang 473000 China |
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Abstract Objective To investigate the efficacy of ulcer decoction combined with rabeprazole in the treatment of hp-associated duodenal ulcer and its effect on the serum Nuclear factor kappa-B（NF-B） and Tumor necrosis factor-（TNF-）.Methods According to the random number table method,96 cases of hpa-associated duodenal ulcer patients admitted to the department of gastroenterology of our hospital were divided into control group and observation group,48 cases each.The control group was treated with rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules,and the observation group was treated with ulcer decoction based on rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules.Serum levels of NF-B and TNF- were compared before and after treatment.Results the total clinical effective rate of the observation group was 93.75%,significantly higher than that of the control group（77.08%）（P< 0.05）.after treatment,the serum levels of TNF- and NF- B in both groups were significantly lower than those before treatment（P< 0.05）,and the serum levels of the above two indicators in the observation group were significantly lower than those in the control group（P<0.05）.the eradication rate of Hp in the observation group was 93.75%,significantly higher than that in the control group（72.92%）（P< 0.05）.The recurrence rate of the observation group was 10.42%,significantly lower than that of the control group（18.75%）（P< 0.05）.Conclusion Ulcer decoction combined with rabeprazole is effective in the treatment of hp-associated duodenal ulcer,which can effectively eradicate Hp,reduce the rate of disease recurrence,and reduce the serum levels of NF- B and TNF- in patients.
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Received: 20 May 2020
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[1] 王吉耀,廖二元,胡品津.内科学[M].北京:人民卫生出版社,2005:421.
[2] 郑筱萸. 中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:151-155.
[3] 胡玲,程明,李培武,等.不同证候舌苔HSP70、IL-8 mRNA表达与胃黏膜HP感染和病理改变的关联[J].北京中医药大学学报,2016,39(8):653-658.
[4] 黄劲华. 奥美拉唑联合阿莫西林、甲硝唑对消化性溃疡进行治疗的临床效果观察[J].中国社区医师:医学专业,2013,27(8):71-72.
[5] 万水祥. 丽珠胃三联联合奥美拉唑治疗62例Hp阳性消化性溃疡[J].现代诊断与治疗,2015,16(5):304.
[6] 胡玲,程明,李培武,等.不同证候舌苔HSP70、IL-8 mRNA表达与胃黏膜HP感染和病理改变的关联[J].北京中医药大学学报,2016,39(8):653-658. |
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2021, Vol. 41 
