生长抑素联合艾司奥美拉唑治疗肝硬化合并上消化道出血的应用价值分析

doi:10.3969/j.issn.1001-8131.2026.02.003

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Abstract Objective This study aims to observe the clinical efficacy of the combined therapy with the two drugs. Methods All patients were randomLy divided into two groups:52 patients were treated with esomeprazole alone(control group),and 53 patients were treated with somatostatin combined with esomeprazole(observation group).The clinical efficacy,coagulation function and liver function levels were compared between the two groups. Results The overall clinical efficacy and clinical effective rate were both superior in the observation group(Z=-5.057, P=0.000;χ²=7.244, P=0.008).After treatment,the fibrinogen(Fib)level was elevated,while prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly decreased in both groups compared with those before treatment(P<0.05),and the improvements in the observation group were more significant(t=5.847, P=0.000;t=-8.337, P=0.000;t=-8.235, P=0.000).The liver function indexes were reduced in both groups after treatment(P<0.05),with more prominent improvements in the observation group(t=-13.564, P=0.000;t=-8.228, P=0.000;t=-12.841, P=0.000). Conclusion Somatostatin combined with esomeprazole can achieve satisfactory hemostatic effect,improve the coagulation function and liver function of patients,with favorable clinical efficacy,which is worthy of clinical promotion and application.

Key words： Somatostatin Esomeprazole for Injection Liver Cirrhosis Upper Gastrointestinal Bleeding

Received: 02 March 2026

PACS:

R657.3+1

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	Articles by authors
	Gou Xi
	Yang Jing
	Liu Min

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Gou Xi,Yang Jing,Liu Min. Application Value Analysis of Somatostatin Combined with Esomeprazole in the Treatment of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding[J]. journal1, 2026, 46(2): 11-13.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.02.003 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I2/11

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