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| Correlation Analysis of Serum 25-Hydroxyvitamin D Levels and Antibody Titers in Autoimmune Thyroid Diseases |
| Sun Fei, Wang Zhuan |
| Department of laboratory medicine,Wolong District Hospital of traditional Chinese medicine,Nanyang,Henan 473000 |
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Abstract Objective To investigate the correlation between serum 25-hydroxyvitamin D [25-（OH）D]levels and the titers of The presence of thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)in individuals with autoimmune thyroid disease（AITD）,and to explore its clinical significance.Methods A total of 102 patients with AITD admitted to the Department of internal medicine of Wolong District Hospital of traditional Chinese medicine in Nanyang from June 2024 to December 2025 were selected retrospectively as the research group,the Control Group consisted of 102 healthy individuals who underwent physical examination in the same period.Serum levels of 25-（OH）D,TPOAb,and TgAb were detected and compared between the two groups.The Study Group was further divided into deficiency,insufficiency,and sufficiency subgroups based on 25-（OH）D levels.The differences in antibody titers among subgroups were compared,and the correlation between serum 25-（OH）D and TPOAb/TgAb was analyzed using Spearman correlation coefficient.Results A significantly reduced level of serum 25-(OH)D was observed in the study group relative to the healthy controls,while the levels of TPOAb and TgAb were higher than those in the control group,with statistically significant differences(P<0.05).Subgroup analysis showed that the levels of TPOAb and TgAb in the deficiency subgroup were significantly higher than those in the insufficiency subgroup and the sufficiency subgroup,and the insufficiency subgroup was also significantly higher than the sufficiency subgroup(P<0.05).Spearman correlation analysis indicated that the serum 25-(OH)D level in AITD patients was significantly negatively correlated with the titers of TPOAb and TgAb(P<0.001).Conclusions Vitamin D deficiency is prevalent in AITD patients.Low levels of 25-（OH）D are closely associated with high titers of thyroid autoantibodies,suggesting that Vitamin D may participate in the pathological process of AITD as an immunomodulator.Monitoring its level has important reference value for assessing disease condition and guiding treatment.
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Received: 30 March 2026
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2026, Vol. 46 
