血清BDNF、Ghrelin、MPO水平对冠心病患者PCI术后抑郁发作的预测价值分析

doi:10.3969/j.issn.1001-8131.2026.05.001

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (615 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the predictive value of serum levels of brain-derived neurotrophic factor(BDNF),ghrelin,and myeloperoxidase(MPO)for postoperative depressive episodes in patients with coronary heart disease undergoing percutaneous coronary intervention(PCI). Methods A total of 200 patients with coronary heart disease who underwent PCI in our hospital from July 2020 to September 2022 were prospectively enrolled.Based on the occurrence of depressive episodes within three months after surgery,patients were divided into a depression group(n=117)and a non-depression group(n=83).Relevant clinical data were collected.Univariate analysis and multivariate logistic regression analysis were used to assess the correlations between BDNF,ghrelin,and MPO levels and postoperative depressive episodes.Receiver operating characteristic(ROC)curves were used to evaluate the individual and combined predictive values of BDNF,ghrelin,and MPO for depressive episodes. Results Univariate and multivariate logistic regression analyses showed that BDNF(OR=0.486,95%CI=0.377-0.701,P<0.001),ghrelin(OR=0.529,95%CI=0.324-0.863,P=0.011),and MPO(OR=1.235,95%CI=1.033-1.352,P<0.001)were independent risk factors for depressive episodes.ROC curve analysis showed that the areas under the curve for BDNF,ghrelin,and MPO alone in predicting depressive episodes were 0.729(95%CI=0.661-0.798),0.729(95%CI=0.659-0.800),and 0.775(95%CI=0.708-0.842),respectively,while the area under the curve for the combined prediction was 0.879(95%CI=0.829-0.928). Conclusion Serum BDNF,Ghrelin and MPO are closely related to postoperative depressive episodes in patients with coronary heart disease before PCI,and single or combined detection has a good predictive effect,which can provide a basis for clinical prevention of depressive episodes.

Key words： Coronary heart disease Percutaneous coronary intervention Depressive episodes Brain-Derived Neurotrophic Factor Ghrelin Myeloperoxidase

Received: 20 April 2026

PACS:

R541.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Li Hongjie
	Li Peng
	Ma Yulian
	Xie Zhijiang
	Li Qin
	Guo Junhua
	Li Zhimei
	Song Wei

Cite this article:

Li Hongjie,Li Peng,Ma Yulian, et al. Predictive Value of Serum BDNF,Ghrelin and MPO Levels in Patients with Coronary Heart Disease after PCI[J]. journal1, 2026, 46(5): 1-5.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.05.001 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I5/1

[1] 李敏,孙杨,邱瑞瑾,等.冠心病相关中医证候DNA甲基化研究进展[J].中国中西医结合杂志,2019,39(04):509-512.
[2] 刘毅,耿洪娇,崔鑫,等.注射用灯盏花素治疗急性脑梗死和冠心病心绞痛的临床综合评价[J].中草药,2023,54(19):6413-6423.
[3] 高立建,袁晋青.经皮冠状动脉介入治疗技术和器械进展[J].中华心血管病杂志,2022,50(02):112-116.
[4] 王娟,张雨龙,钟怡,等.经皮冠状动脉介入治疗伴发焦虑及抑郁情绪研究进展[J].中国全科医学,2020,23(23):2938-2943.
[5] 张鹏鹏. 持续和间歇运动上调PGC-1α/Irisin/BDNF表达改善肥胖小鼠认知功能障碍[J].中国生物化学与分子生物学报,2023,39(09):1346-1355.
[6] 张碧涛,李媛媛,辛泰然,等.逍遥散治疗抑郁症的研究进展[J].中国实验方剂学杂志,2022,28(23):273-282.
[7] 杜敏,沈虹,冯骁腾,等.调心方治疗冠心病伴焦虑/抑郁患者临床疗效及对血清5-HT、β-TG、MPO水平的影响[J].中国实验方剂学杂志,2023,29(05):150-157.
[8] 汪向东,王希林,马弘.心理卫生评定量表手册(增订版)[M].北京:中国心理卫生杂志社,1999:196.
[9] Rampidis GP,Benetos G,Benz DC,et al.A guide for Gensini score calculation[J].Atherosclerosis,2019,287:181-183.
[10] 肖水源. 《社会支持评定量表》的理论基础与研究应用[J].临床精神医学杂志,1994(02):98-100.
[11] 买力曼·巴哈尼,萨拉瓦提·哈日特别克,聂艳武,等.基于年龄-时期-队列模型分析2006—2020年中国冠心病死亡趋势[J].现代预防医学,2023,50(02):193-198.
[12] 徐亚宁,丁翔,邹勇,等.冠心病患者PCI术后感染病原菌、耐药性及危险因素分析[J].中国病原生物学杂志,2019,14(04):464-467.
[13] 余天浩,李瑜辉,伍灏堃,等.血清BDNF和Ghrelin水平与冠心病介入术后并发抑郁症的关系[J].中山大学学报(医学版),2018,39(05):717-723.
[14] 杨潇,董再全,王瑜,等.抑郁症病因学和治疗学的研究进展[J].中国科学:生命科学,2022,52(11):1678-1691.
[15] 李册兴,吕建峰,万少枝,等.急性冠脉综合征患者介入治疗后抑郁症状风险的列线图预测模型[J].中国心理卫生杂志,2023,37(09):771-779.
[16] 蔡剑梅,莫素娟,周明明,等.炎症性肠病住院患者营养风险与抑郁情绪、心理弹性及自我管理行为的关系[J].中国健康心理学杂志,2023,31(04):514-518.
[17] 王静,陈洁.高血压合并焦虑、抑郁患者血清炎症因子和单胺类递质水平的变化[J].中华高血压杂志,2023,31(08):769-772.
[18] 曹旭然,张阔,杜亚欣,等.恶性血液病患者自我效能对抑郁的影响:社会支持的中介作用与心理弹性的调节作用[J].中华行为医学与脑科学杂志,2023,32(05):420-425.
[19] 王钦,刁丽梅,蔡萧君.基于BDNF/CREB信号通路探讨巴戟天对慢性应激抑郁大鼠海马神经元损伤的影响[J/OL].中华中医药学刊:1-9[2023-10-18].http://kns.cnki.net/kcms/detail/21.1546.R.20230811.1018.002.html.
[20] 伍灏堃,余天浩,李瑜辉,等.冠心病合并抑郁患者血清脑源性神经营养因子、胃饥饿素与认知功能的相关性[J].中国老年学杂志,2019,39(18):4372-4375.
[21] 杜敏,沈虹,冯骁腾,等.调心方治疗冠心病伴焦虑/抑郁患者临床疗效及对血清5-HT、β-TG、MPO水平的影响[J].中国实验方剂学杂志,2023,29(05):150-157.