脂肪酸结合蛋白4与缺血性卒中后认知功能障碍的相关性研究

doi:10.3969/j.issn.1001-8131.2026.05.002

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (439 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the association between the level of fatty acid binding protein 4(FABP4)in circulating blood and post-stroke cognitive impairment(PSCI)after acute ischemic stroke. Methods A total of 114 patients with acute ischemic stroke treated in the neurology department of our hospital were included.According to the Mini-Mental State Examination(MMSE)score,the participants were divided into the cognitive impairment group(32 cases)and the non-cognitive impairment group(82 cases).Demographic characteristics,past medical history,lifestyle information,fasting blood glucose,lipid profile,homocysteine,and serum FABP4 concentration of all study subjects were collected.Additionally,visceral fat area was evaluated by abdominal CT.Univariate analysis was first conducted to compare the differences in various indicators between different groups,and then the items with significant differences were further analyzed by multivariate Logistic regression to obtain the related risk factors for PSCI after acute ischemic stroke.Moreover,Pearson correlation analysis was used to assess the linear relationship between visceral fat,FABP4,and PSCI. Results Multivariate analysis indicated that advanced age(OR=2.223),high homocysteine(OR=1.895),high serum FABP4(OR=3.104),and high visceral fat content(OR=2.625)were all influencing factors for the occurrence of PSCI.The Results of correlation analysis showed that visceral fat area(r=0.645)and serum FABP4 level(r=0.588)were significantly positively correlated with PSCI(P<0.001 for both). Conclusion In patients with acute ischemic stroke,elevated serum FABP4 concentration,visceral fat accumulation,advanced age,and hyperhomocysteinemia are independent predictors of PSCI,and FABP4 and visceral fat content have a clear positive association with the occurrence of cognitive impairment.

Key words： Fatty acid binding protein 4 Ischemic stroke Post-stroke cognitive impairment Visceral fat Risk factors

Received: 01 April 2026

PACS:

R743.3

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.05.002 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I5/6

[1] 刘颖,王海丽,刘静.缺血性脑卒中后胃肠功能障碍与血清瓜氨酸,肠型脂肪酸结合蛋白,肠三叶因子水平的关系[J].中西医结合心脑血管病杂志,2022,20(21):4008-4011.
[2] 宋志秀,牛晓露,李文惠,等.血管内皮钙黏蛋白与急性缺血性脑卒中静脉溶栓后出血转化的相关性分析[J].中西医结合心脑血管病杂志,2022,20(11):2080-2083.
[3] 刘杰,任晓艳,张昊.缺血性脑卒中急性期认知障碍危险因素及其与Lp-PLA2,VILIP-1的相关性[J].中西医结合心脑血管病杂志,2021,19(16):2833-2837.
[4] 孟凤琴,李玉静,苗蕊.血清髓过氧化物酶,低密度脂蛋白表达与缺血性脑卒中后认知功能障碍的相关性分析[J].中西医结合心脑血管病杂志,2022,20(13):2446-2449.
[5] 周小炫,谢敏,陶静,等.简易智能精神状态检查量表的研究和应用[J].中国康复医学杂志,2016(6):694-696.
[6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[7] 李贵友,陈显兵,袁林,等.延龄草总皂苷对缺血卒中后认知障碍大鼠Tau蛋白磷酸化及p38MAPK/NF-κB通路的影响[J].现代中西医结合杂志,2024,33(18):2489-2495.
[8] 邢佳佳,白鸣一.肠型脂肪酸结合蛋白,Toll样受体4,肠三叶因子与脑卒中患者胃肠功能障碍的相关性研究[J].中国微侵袭神经外科杂志,2023,27(12):123-126.
[9] 李攀,刘玉洁,高晓娟,等.血清FABP4,D-Dimer,GFAP,PCT水平和联合检测对缺血性脑卒中早期诊断与预后评估的价值研究[J].宁夏医学杂志,2025,47(5):395-398.
[10] 韩荣坤,许月光,刘景峰,等.血清细胞间黏附分子1,脂蛋白相关磷脂酶A2与急性缺血性脑卒中患者认知功能障碍相关性研究[J].临床军医杂志,2024,52(6):609-611.