复方甘草酸苷注射液辅助治疗小儿过敏性紫癜肾炎的疗效及对细胞因子的影响

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (289 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the therapeutic effect of compound glycyrrhizin injection in adjuvant treatment of children with Henoch-Schonlein purpura nephritis(HSPN) and the influence on cytokines.Methods A total of 60 children with HSPN were randomized into two groupA and group B,30 cases in each group.Group A was given conventional treatment,and group B was treated with compound glycyrrhizin injection on the basis of conventional treatment.After 4 weeks of treatment,clinical effects were observed.Changes in urine protein quantification,urine erythrocyte,serum creatinine,urine microalbumin (MAlb) and cytokines [interleukin-4 (IL-4),γ-interferon (IFN-γ)] were compared between groups.Results After 4 weeks of treatment,the total response rate of group B (90.00%) was significantly higher than that of group A(66.67%)(P<0.05).After treatment,urinary protein quantification,urine erythrocyteand serum creatinine of both groups were significantly decreased,and urine microalbumin (MAlb) significantly increased (P<0.05).Besides,the above indexes in group B were better than group A(P<0.05).IL-4 levels in both groups significantly decreased,andIFN-γ levels significantly increased (P<0.05),which were better in group B than group A(P<0.05).Conclusion Compound glycyrrhizin injection is effective in adjuvant treatment of children with HSPN,which can enhance renal function and regulate cytokine levels.

Key words： Compound glycyrrhizin injection Henoch-Schonlein purpura nephritis in children Cytokine Curative effect

Received: 18 August 2020

PACS:

R246.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Zhang Dan
	Zhang Xiaofei

Cite this article:

Zhang Dan,Zhang Xiaofei. Curative Effect of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children With Henoch-Schonlein Purpura Nephritis and the Influence on Cytokines[J]. journal1, 2021, 41(4): 17-18.

URL:

http://www.hrbyybjb.org.cn/EN/ OR http://www.hrbyybjb.org.cn/EN/Y2021/V41/I4/17

[1]	. [J]. journal1, 2021, 41(5): 70-71.
[2]	. [J]. journal1, 2021, 41(5): 92-92.
[3]	. [J]. journal1, 2021, 41(5): 139-140.
[4]	Liang Menglin, Huang Xiangmin, Tan Xiong. Effect of Vitamin AD on Children With Recurrent Respiratory Tract Infection[J]. journal1, 2021, 41(4): 21-23.
[5]	. [J]. journal1, 2021, 41(4): 35-36.
[6]	. [J]. journal1, 2021, 41(4): 45-46.