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| Clinical Observation of Uterine Intramuscular Injection of Carboprost Tromethamine Injection in the Adjuvant Treatment of Postpartum Hemorrhage Due To Uterine Inertia After Spontaneous Delivery |
| Zhang Wenjing |
| Pingdingshan First People's Hospital,Pingdingshan 467000,China |
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Abstract Objective To investigate the effect of uterine intramuscular injection of carboprost tromethamine injection in the adjuvant treatment of postpartum hemorrhage due to uterine inertia after spontaneous delivery.Methods 90 parturients with postpartum hemorrhage due to uterine inertia after spontaneous delivery were randomly divided into observation group and control group,45 cases in each group.The control group was given conventional treatment for postpartum hemorrhage,and the observation group was treated with uterine intramuscular injection of carboprost tromethamine injection based on the treatment of control group.Therapeutic effects of the 2 groups were compared.Results The total response rate of observation group was significantly higher than that of the control group（P<0.05）.Bleeding volume of the observation group at 2 hours and 24 hours after delivery was less than that of the control group（P<0.05）,the third stage of labor was shorter than the control group（P<0.05）,and postpartum decreased value of hemoglobin was lower than the control group（P<0.05）.Besides,levels of nitric oxide synthase（NOS）,serum nitric oxide（NO）and brain natriuretic peptide（BNP）in the observation group were significantly lower than those in the control group（P<0.05）.HR（heart rate）of both groups was increased significantly,while MAP（mean arterial pressure）,SBP（systolic blood pressure）and DBP（diastolic blood pressure）were significantly reduced at 24 hours after delivery.Meanwhile,MAP,SBP and DBP of the observation group at 24 hours after delivery were significantly higher than those of the control group,and HR was significantly lower than the control group（P<0.05）.The total incidence of adverse reactions in the observation group was 24.44%,significantly lower than 44.44% of the control group（P<0.05）.Conclusion Carboprost tromethamine is effective in the treatment of postpartum hemorrhage due to uterine inertia after spontaneous delivery.It can shorten the third stage of labor,improve postpartum hemorrhage,reduce NO,NOS and BNP levels,and stabilize hemodynamic indexes,with low incidence of adverse reactions.
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Received: 17 December 2020
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2022, Vol. 42 
