血液灌流联合盐酸戊乙奎醚对急性重度有机磷农药中毒患者氧化应激水平影响

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Abstract Objective To observe the effects of hemoperfusion combined with penehyclidine hydrochloride on oxidative stress in patients with severe acute organophosphorus pesticide poisoning. Methods A total of 60 patients with severe acute organophosphorus pesticide poisoning were selected.According to the random number table method,they were divided into hemoperfusion group and combined group,30 cases each.The hemoperfusion group received blood perfusion treatment,while the combination group was treated with penehyclidine hydrochloride on this basis.After treatment,the treatment effect,changes of cholinesterase,changes of stress indicators（SOD,LDH）were observed. Results The cure rate of the combined group was higher than that of the hemoperfusion group,and,the coma time,the total amount of clodidine,atropine,and the length of hospital stay were lower than the hemoperfusion group,the differences were statistically significant（P<0.05）.After treatment,the cholinesterase activity in the combination group was higher than that in the hemoperfusion group（P<0.05）,and the cholinesterase activity returned to normal time was shorter than the hemoperfusion group（P<0.05）.There were no significant differences in SOD,and LDH in the two groups before treatment（all P>0.05）.After treatment,the LDH in the combination group were all not significant.After treatment,and LDH in the combination group were lower than those in the hemoperfusion group（all P<0.05）,and SOD was higher than those in the hemoperfusion group（P<0.05）. Conclusion Hemoperfusion combined with penehyclidine hydrochloride in the treatment of severe acute organophosphorus pesticide poisoning has a significantly improved effect,and can improve the level of stress indicators with high safety.

Key words： Hemoperfusion Penehyclidine hydrochloride Acute severe organophosphorus pesticide poisoning

Received: 03 August 2020

PACS:

R781.6+6

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	Wang Qiuju
	Guo Huimin
	Li Haiyan

Cite this article:

Wang Qiuju,Guo Huimin,Li Haiyan. Effect of Hemoperfusion Combined With Penehyclidine Hydrochloride on Oxidative Stress in Patients With Severe Acute Organophosphorus Pesticide Poisoning[J]. journal1, 2021, 41(5): 5-7.

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http://www.hrbyybjb.org.cn/EN/ OR http://www.hrbyybjb.org.cn/EN/Y2021/V41/I5/5

[1] 黄永禄,王玉兰.有机磷中毒呼吸衰竭的危险因素及PCT水平监测的意义[J].临床肺科杂志,2018,23(11):2087-2090.
[2] 彭强,朱保锋,王蕾,等.氯磷定冲击治疗对重度有机磷农药中毒患者氧化应激损伤及血管内皮功能的影响[J].中国急救复苏与灾害医学杂志,2019,14(10):941-944.
[3] 张文凯,丁宁,李长罗,等.盐酸戊乙奎醚联合硫辛酸对百草枯中毒所致肺纤维化的影响研究[J].现代中西医结合杂志,2019,28(27):2969-2974.
[4] 李艳秋,陈广生,马德渊,等.血液灌流与盐酸戊乙奎醚联合治疗重度急性有机磷农药中毒的效果研究[J].湖南师范大学学报(医学版),2019,16(2):144-147.
[5] 叶任高. 内科学[M].北京:人民卫生出版社,2004:960.
[6] 张威,黄昌保,江云,等.急性重度有机磷农药中毒并发症的发生与毒物种类之间的相关性分析[J].中国急救复苏与灾害医学杂志,2017,12(4):309-311.
[7] 唐雪梅,李勇,李婷婷.有机磷农药中毒致患者呼吸功能衰竭的急救措施与疗效[J].昆明医科大学学报,2018,39(6):71-75.
[8] 李向东. 血液灌流联合盐酸戊乙奎醚注射液治疗急性重度有机磷农药中毒的疗效观察[J].中国基层医药,2017,24(16):2473-2476.
[9] 张娜,许铁.炎症指标(NC、NLR)及APACHEⅡ评分与急性有机磷中毒严重程度的关系[J].中国急救复苏与灾害医学杂志,2019,14(3):218-221.
[10] 王文坤,陈建洪,陈金新.盐酸戊乙奎醚联合血液灌流治疗急性重度有机磷中毒的疗效及其对患者炎性因子和氧化应激的影响[J].海南医学,2018,29(20):2833-2836.
[11] Liu L,Ding G.Effects of different blood purification methods on serum cytokine levels and prognosis in patients with acute severe organophosphorus pesticide poisoning[J].Ther Apher Dial,2015,19(2):185-190.
[12] Liang M J,Zhang Y.Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning[J].Genet Mol Res,2015,14(2):4914-4919.
[13] Wang Y,Gao Y,Ma J.Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride[J].Drug Des Devel Ther,2018,12:3289-3299.