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| Retrospective Study of Simvastatin Tablets Combined With Enalapril Folic Acid Tablets in the Treatment of Patients With Hypertension and Hyperhomocysteinemia |
| Li Guangyun |
| Department of Cardiology,Nanyang Second People's Hospital,Nanyang 473000,China |
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Abstract Objective To explore the efficacy of simvastatin tablets combined with enalapril folic acid tablets in the treatment of patients with hypertension and hyperhomocysteinemia（HHT）. Methods The clinical data of 60 patients with HHT were retrospectively analyzed.30 patients were treated with enalapril folic acid tablets as the conventional group,and 30 patients treated with simvastatin tablets and enalapril folic acid tablets as the combined group.The curative effects of the two groups were compared and the levels of diastolic blood pressure（DBP）,systolic blood pressure（SBP）,serum Hcy,tumor necrosis factorα（TNF-α）,C-reactive protein（CRP）and matrix metalloproteinase-9（MMP-9）levels were compared between the two groups before and after treatment. Results The total effective rate of the combined group was 93.33% higher than that of the conventional group 66.67%（P<0.05）;after treatment,the levels of DBP,SBP and serum Hcy in the combined group were lower than those in the conventional group（P<0.05）;after treatment,the levels of TNF -α,CRP and MMP-9 in the combined group were lower than those in the conventional group（P<0.05）. Conclusion Simvastatin tablets combined with enalapril folic acid tablets in the treatment of HHT patients can reduce the levels of serum Hcy and inflammatory factors,improve the effect of blood pressure control,with a significant effect.
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Received: 16 November 2020
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2021, Vol. 41 
