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| Efficacy of Sodium Valproate in the Treatment of Epilepsy Children of Different Ages and Monitoring Analysis of Its Blood Concentration |
| Liu Ruiting, Cui Nana |
| Department of Pediatrics,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China |
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Abstract Objective To explore the curative effect of sodium valproate on children with epilepsy of different ages and the monitoring effect of plasma drug concentration.Methods 90 children with epilepsy were selected as subjects.All children were treated with sodium valproate,and the plasma concentration of sodium valproate was monitored to analyze the distribution of the plasma concentration of sodium valproate in children of different ages.And evaluate the therapeutic effect of children with different plasma concentrations of sodium valproate.Results The results showed that the blood concentration of sodium valproate in children less than 3 years old was significantly higher than that in other two groups（P<0.05）.The blood concentration of sodium valproate（50-100μg/mL）in children aged 3-5 years and 6-12 years was significantly higher than that in children aged less than 3 years（P<0.05）.The poisoning rate of blood drug concentration > 100μg/mL was higher than that of the other two groups（P<0.05）,and the total effective rate of blood drug concentration<50μg/mL was significantly lower than that of the other two groups（P<0.05）.Conclusion There are obvious differences in serum concentration levels of epileptic children of different ages after receiving sodium valproate treatment,and there are also great differences in therapeutic effects for children with different serum concentration of sodium valproate.Therefore,it is necessary to adjust the medication regimen according to the specific situation of children and monitor the blood drug concentration in time to improve the therapeutic effect of sodium valproate.
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Received: 05 January 2022
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2023, Vol. 43 
