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| Effect of Aspirin Combined with Dydrogesterone on Endometrial Receptivity and Insulin Resistance in Obese Patients with PCOS |
| Wei Chunhua, Li Haiyan, Zhu Shuping |
| Sui County Hospital of Traditional Chinese Medicine,Henan 476900,China |
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Abstract Objective To observe the effects of aspirin combined with dydrogesterone on endometrial receptivity（ER）and insulin resistance（IR）in patients with obesity polyovary syndrome（PCOS）.Methods 110 cases of obese PCOS patients treated in our hospital were selected as the research objects,and they were divided into experimental group and control group with 55 cases each according to the random number table method.The control group was treated with dydrogesterone,and the experimental group was treated with aspirin in the control group.Before and after one cycle of treatment,observe the levels of sex hormones [testosterone（T）,luteinizing hormone（LH）,follicle stimulating hormone（FSH）],ER ultrasound examination indicators [Endometrial thickness,uterine artery blood flow pulsation index（PI）,resistance index（RI）] and insulin index [insulin resistance index（HOMA-IRI）,insulin secretion function index（HOMA-β）] of the two groups.The total incidence of adverse drug reactions in the two groups during the course of treatment and the difference in the pregnancy rates of the two groups within six months after treatment were analyzed.Results After one cycle of treatment,the levels of sex hormones（T,LH,FSH）,ER ultrasound examination indicators（PI,RI）,and insulin indicators（HOMA-IRI,HOMA-β）in the two groups were significantly lower than before treatment.And the experimental group was significantly lower than the control group at the same time（both P<0.05）.The endometrial thickness of the two groups was significantly higher than before treatment,and the experimental group was significantly higher than the control group at the same time（both P<0.05）.During the course of treatment,there was no significant difference in the overall incidence of adverse drug reactions between the two groups of patients（P>0.05）.Within six months after treatment,the pregnancy rate in the experimental group was significantly higher than that in the control group at the same time（P<0.05）.Conclusions Aspirin combined with dydrogesterone can achieve good results in the treatment of obese PCOS patients.Sex hormone levels tend to decrease,ER will increase,and insulin secretion will decrease.It can increase the pregnancy rate of patients,and the drug is safe,which is worthy of clinical popularization.
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Received: 21 May 2022
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2023, Vol. 43 
