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| Effects of Different Aspirin Regimens on Gamma Globulin Dosage and Liver Function of Children Patients With Kawasaki Disease |
| Zhao Jiayan |
| The third Affiliated Hospital of Xinxiang Medical College Pediatrics,Xinxiang 453000,China |
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Abstract Objective To observe the effects of different aspirin regimens on gamma globulin dosage and liver function of children patients with Kawasaki disease（KD）. Methods 86 children patients with KD who were admitted to our hospital for treatment were selected and randomly divided into control group and observation group,with 43 cases in each group.Both groups were treated with gamma globulin combined with aspirin,and the children patients in observation group gradually reduced the aspirin dose after fever subsided,and the children patients in control group directly reduced the aspirin dose after fever subsided.The efficacy after 6 weeks of treatment,relief times of various clinical symptoms,average dose of gamma globulin and adverse drug reactions were compared between the two groups.The liver function indexes[aspartate minotransferase（AST）,alanine aminotransferase（ALT）,glutamyltransferase（GGT）] were compared between the two groups before treatment and after 6 weeks of treatment. Results After 6 weeks of treatment,the total effective rate of treatment in observation group was significantly higher than that in control group（P<0.05）.The relief times of symptoms such as cervical lymph node swelling and diffuse mucosal hyperemia in observation group were significantly shorter than those in control group,and the re-injection rate of gammaglobulin was significantly lower than that in control group（P<0.05）.The levels ofAST,ALTand GGT in the two groups were significantly lower than those before treatment,and the levels in observation group were significantly lower than those in control group during the same period（P<0.05）.There were no significant differences in the adverse drug reactions between the two groups（P>0.05）. Conclusion Aspirin combined with gamma globulin in the treatment of Kawasaki disease can speed up the disappearance of clinical symptoms and improve the efficacy,with high clinical promotion value.
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Received: 01 December 2020
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2021, Vol. 41 
