Effect of Jiawei Zhenwu Decoction on renal fibrosis and renal function in patients with chronic kidney disease of spleen-kidney yang deficiency
Liu Lingyi1, Liu Hongwei2, Niu Xiping1
1. Dialysis room of Nephrology Department of Luohe Hospital of traditional Chinese medicine;Luohe 462000,Henan,China; 2. Wuyang County People's Hospital; Wuyang County 462400,Henan,China
AbstractObjective To analyze the effect of Jiawei Zhenwu decoction on renal fibrosis and renal function in patients with chronic kidney disease（CKD） stage 2-3 of spleen-kidney yang deficiency type.Methods 76 patients with chronic kidney disease（CKD） stage 2-3 of spleen-kidney yang deficiency type were selected and randomly divided into a control group（n=38） and a test group（n=38）.The control group was treated with conventional western medicine,and the test group was treated with Jiawei Zhenwu Decoction on the basis of the control group.The curative effect,TCM syndrome score,renal fibrosis[hyaluronic acid（HA）,collagen Ⅳ（Col Ⅳ）] and renal function [blood urea nitrogen（BUN）,creatinine（SCR）] of the two groups were compared.Results The total effective rate of the test group94.74%（36/38） was higher than that of the control group（71.05%（27/38）（P<0.05）;Compared with the control group,the TCM syndrome score of the test group after treatmentwas lower（P<0.05）;Compared with the control group,the levels of HA and Col - Ⅳ in the test group after treatment were lower（P<0.05）;Compared with the control group,the levels of BUN and SCR in the test group after treatment were lower（P<0.05）.Conclusion The application of Jiawei Zhenwu decoction in the treatment of chronic kidney disease with spleen-kidney yang deficiency type can significantly improve the therapeutic effect,relieve clinical symptoms,inhibit renal fibrosis,improve renal function,and has outstanding clinical application value.
Liu Lingyi,Liu Hongwei,Niu Xiping. Effect of Jiawei Zhenwu Decoction on renal fibrosis and renal function in patients with chronic kidney disease of spleen-kidney yang deficiency[J]. journal1, 2023, 43(3): 132-134.
[1] 赵涛,苏涛.慢性肾脏病患者铁代谢障碍及缺氧诱导因子脯氨酰羟化酶抑制剂对铁代谢的改善作用[J].中华医学杂志,2021,101(16):1195-1198. [2] Ahmad M Radaideh,Ziad A Audat,Abdulkarim W Sunallah,et al.A Simultaneous Rupture of the Patellar Tendon and the Con-tralateral Quadriceps Tendon in a Patient with Chronic Renal Failure Undergoing Long Term Hemodialysis[J].Med Arch,2021,75(4):317-320. [3] 杨红利. “通阳不在温,而在利小便”在慢性肾脏病治疗中的运用[J].中国民间疗法,2021,29(23):4-6. [4] 张月红,王彤,宋锦华,等.透析前慢性肾衰竭患者中医辨证分型与血清β2微球蛋白、肌酐水平的相关分析[J].中国中医药科技,2017,24(3):263-265. [5] 刘晓城. 肾脏病诊疗指南[M].科学出版社,2005. [6] 国家中医药管理局.中药新药临床研究指导原则[M].中国医药科技出版社,2002:163. [7] 谷裕,任东升,陶雅非.百令胶囊联合肾康注射液在慢性肾衰竭治疗中的价值分析[J].临床医学,2019,39(6):116-117. [8] Dirk Pabst,Patricio A Sanchez-Cueva,Behzad Soleimani,et al.Predictors for acute and chronic renal failure and survival in patients supported with veno-arterial extracorporeal membrane oxygenation[J].Perfusion,2020,35(5):402-408. [9] 张灵灵. 血液透析联合血液灌流治疗老年血液透析合并慢性肾脏病矿物质和骨代谢异常的效果及对BMP、iPTH、甲状腺素水平的影响[J].中国老年学杂志,2018,38(9):2168-2170. [10] 徐启明,路建饶.中医药疗法治疗慢性肾脏病的研究进展[J].当代医药论丛,2021,19(12):8-10. [11] 庄新鸿,陈文,庄乙君,李丽花.血液透析治疗慢性肾脏病患者的效果及对肾纤维化、肾功能等的影响[J].疑难病杂志,2018,17(3):235-238. [12] 王艳艳. 肾气丸合真武汤对脾肾阳虚型慢性肾衰竭患者SCr、BUN、Ccr的影响[J].中国实用医药,2020,15(33):129-131. [13] 张矿军,张盼盼,孙丹丹.中西医结合治疗脾肾阳虚型早中期慢性肾衰竭53例临床观察[J].中国民族民间医药,2020,29(15):94-96,99. [14] 马春成,伍劲华,李叶枚.真武汤联合中药灌肠对慢性肾衰竭的疗效及免疫功能、肾脏血流的影响[J].世界中西医结合杂志,2022,17(1):165-169,174. [15] 刘钊. 加味真武汤辅助治疗对慢性肾小球肾炎患者尿素氮、肌酐水平的影响[J].临床医学工程,2020,27(11):1473-1474.
2023, Vol. 43 
