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哈尔滨医药  2025, Vol. 45 Issue (1): 8-10    DOI: 10.3969/j.issn.1001-8131.2025.01.003
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入院时NIHSS评分联合血浆Copeptin、D-二聚体对急性缺血性脑卒中患者的病情进展评估价值分析
卢克红
临沂市中医医院北城医院急诊科,山东 临沂 276000
Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke
Lu Kehong
Emergency Department of Beicheng Hospital,Linyi Traditional Chinese Medicine Hospital,Linyi,Shandong,276000 China
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摘要 目的 探究入院时美国国立卫生研究院卒中量表(NIHSS)评分联合血浆和肽素(Copeptin)、D-二聚体对急性缺血性脑卒中(AIS)患者的病情进展评估价值。方法 选取AIS患者90例进行研究,依据入院NIHSS评分分为轻中度组(≤15分,n=67)和重度组(>15分,n=23),纳入同期体检的健康人员40例为健康组。比较NIHSS评分、血浆Copeptin、D-二聚体水平差异,分析Copeptin、D-二聚体水平与AIS患者病情进展的相关性,二元logistic分析Copeptin、D-二聚体水平与病情进展的关系,ROC分析Copeptin和D-二聚体对AIS患者病情进展的评估价值。结果 AIS组和重度组患者NIHSS评分和Copeptin、D-二聚体水平高于健康组和轻中度组(P<0.05);Copeptin、D-二聚体水平与AIS患者病情进展呈正相关(P<0.05);二元logistics回归分析显示,Copeptin和D-二聚体水平是AIS患者病情进展的相关影响因素(P<0.05);ROC结果显示,Copeptin和D-二聚体评估AIS患者病情进展的AUC分别为0.933、0.969,联合诊断的AUC为0.988,敏感度为95.65%,特异度为82.09%。结论 AIS患者病情进展的血浆Copeptin、D-二聚体水平较高,与入院NIHSS评分有一定相关性,是病情进展的相关影响因素,临床诊断有一定参考价值。
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卢克红
关键词 急性缺血性脑卒中NIHSS评分和肽素D-二聚体病情进展    
AbstractObjective To explore the value of National Institutes of Health Stroke Scale(NIHSS)score combined with plasma and peptidogysin(Copeptin)and D-dimer for disease progression in patients with acute ischemic stroke(AIS). Methods 90 AIS patients were selected for the study.According to the NIHSS score,they were mild into moderate group(15 points,n=67)and severe group(>15 points n=23),and 40 healthy patients included in the physical examination in the same period were healthy group.Comparing differences in NIHSS scores,plasma Copeptin and D-dimer levels,analyzed the correlation between Copeptin and D-dimer levels and disease progression in AIS patients,binary logistic analyzed the relationship between Copeptin and D-dimer levels and disease progression,and ROC analyzed the value of Copeptin and D-dimer on disease progression in AIS patients. Results NIHSS score and Copeptin and D-dimer levels in AIS and severe group were higher than healthy and mild to moderate groups(P<0.05);Copeptin,D-dimer levels were positively correlated with disease progression in AIS patients(P<0.05);Binary logistics regression analysis showed that,Copeptin And D-dimer levels were related factors affecting disease progression in AIS patients(P<0.05);ROC result display,The AUC of Copeptin and D-dimer evaluation for the disease progression in AIS patients were 0.933 and 0.969,respectively,The AUC for the combined diagnosis was 0.988,A sensitivity of 95.65%,The specificity ratio was 82.09%. Conclusion The plasma levels of Copeptin and D-dimer in AIS patients are high,which are correlated with admission NIHSS score,are the relevant influencing factors of disease progression,and have certain reference value in clinical diagnosis.
Key wordsacute ischemic stroke    NIHSS score    and peptidomin    D-dimer    disease progression
收稿日期: 2025-02-15     
PACS:  R743.3  
引用本文:   
卢克红. 入院时NIHSS评分联合血浆Copeptin、D-二聚体对急性缺血性脑卒中患者的病情进展评估价值分析[J]. 哈尔滨医药, 2025, 45(1): 8-10.
Lu Kehong. Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke. journal1, 2025, 45(1): 8-10.
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