Abstract：Objective To investigate the distribution characteristics of pathogens and risk factors of ventilator-associated pneumonia in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）. Methods 74 patients with acute exacerbation of COPD complicated with ventilator-associated pneumonia and 74 patients without ventilator-associated pneumonia were selected as study subjects from our hospital and were divided into the ventilator-associated pneumonia group and the control group.Deep respiratory tract secretions were collected for pathogenic microorganism typing and identification.Demographic characteristics and clinical data were collected,and the levels of serum C-reactive protein,tumor necrosis factor-α,and procalcitonin were measured. Results A total of 86 pathogens were detected in patients with acute exacerbation of COPD complicated with ventilator-associated pneumonia,including 54 Gram-negative bacilli（62.79%）,with Pseudomonas aeruginosa,Acinetobacter baumannii,Klebsiella pneumoniae,and Escherichia coli being the most common in descending order.There were 28 Gram-positive bacteria（32.56%）,with Staphylococcus aureus（14 strains,16.28%）,Streptococcus pneumoniae（8 strains,9.30%）,and Staphylococcus epidermidis（6 strains,6.98%）being the most common in descending order.There were 4 fungi（4.65%）.The proportion of smoking history,diabetes history,SOFA score at admission,APACHE II score,endotracheal intubation,nasogastric tube placement,duration of ventilator support,proportion of parenteral nutrition,and levels of C-reactive protein（79.61±8.35）mg/L,tumor necrosis factor-α（173.57±17.80）ng/L,and procalcitonin（6.59±1.36）μg/L were significantly higher in the ventilator-associated pneumonia group than in the control group,with statistically significant differences（P<0.01）.Multivariate logistic regression analysis showed that endotracheal intubation,nasogastric tube placement,duration of ventilator support,C-reactive protein,tumor necrosis factor-α,and procalcitonin were independent risk factors for ventilator-associated pneumonia. Conclusion The most common pathogens causing ventilator-associated pneumonia in patients with acute exacerbation of COPD were Pseudomonas aeruginosa,followed by Acinetobacter baumannii and Staphylococcus aureus.Risk factors included endotracheal intubation,nasogastric tube placement,duration of ventilator support,C-reactive protein,tumor necrosis factor-α,and procalcitonin.
任园园. 冠心病患者PCI后心肌灌注情况与治疗预后的关系分析[J]. 哈尔滨医药, 2025, 45(1): 11-13.
Ren Yuan Yuan. Distribution Characteristics of Pathogens and Risk Factors of Ventilator-Associated Pneumonia in Patients with Acute Exacerbation of COPD. journal1, 2025, 45(1): 11-13.
2025, Vol. 45 
