Abstract：Objective To explore the value of National Institutes of Health Stroke Scale（NIHSS）score combined with plasma and peptidogysin（Copeptin）and D-dimer for disease progression in patients with acute ischemic stroke（AIS）. Methods 90 AIS patients were selected for the study.According to the NIHSS score,they were mild into moderate group（15 points,n=67）and severe group（>15 points n=23）,and 40 healthy patients included in the physical examination in the same period were healthy group.Comparing differences in NIHSS scores,plasma Copeptin and D-dimer levels,analyzed the correlation between Copeptin and D-dimer levels and disease progression in AIS patients,binary logistic analyzed the relationship between Copeptin and D-dimer levels and disease progression,and ROC analyzed the value of Copeptin and D-dimer on disease progression in AIS patients. Results NIHSS score and Copeptin and D-dimer levels in AIS and severe group were higher than healthy and mild to moderate groups（P<0.05）;Copeptin,D-dimer levels were positively correlated with disease progression in AIS patients（P<0.05）;Binary logistics regression analysis showed that,Copeptin And D-dimer levels were related factors affecting disease progression in AIS patients（P<0.05）;ROC result display,The AUC of Copeptin and D-dimer evaluation for the disease progression in AIS patients were 0.933 and 0.969,respectively,The AUC for the combined diagnosis was 0.988,A sensitivity of 95.65%,The specificity ratio was 82.09%. Conclusion The plasma levels of Copeptin and D-dimer in AIS patients are high,which are correlated with admission NIHSS score,are the relevant influencing factors of disease progression,and have certain reference value in clinical diagnosis.
卢克红. 入院时NIHSS评分联合血浆Copeptin、D-二聚体对急性缺血性脑卒中患者的病情进展评估价值分析[J]. 哈尔滨医药, 2025, 45(1): 8-10.
Lu Kehong. Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke. journal1, 2025, 45(1): 8-10.
2025, Vol. 45 
