Abstract：Objective To investigate the efficacy of silver ion gel combined with hyperbaric oxygen therapy in patients with diabetic foot ulcers.Methods A total of 48 patients who received hyperbaric oxygen therapy were included as the control group,while another 47 patients treated with silver ion gel in addition to the same treatment served as the observation group.The control group（n=48）underwent conventional treatment and local hyperbaric oxygen therapy,whereas the observation group（n=47）received additional silver ion gel application.The efficacy,lower limb microcirculation and hemodynamic parameters,ulcer size,granulation tissue condition,transcutaneous oxygen pressure（TcPO2）,skin temperature,ankle-brachial index,serum markers,and adverse reactions were compared between the two groups.Results The overall efficacy rate was significantly higher in the observation group（91.49%）than in the control group（75.00%,P<0.05）.Post-treatment,the observation group showed significantly better results in TcPO2（59.41±3.18）,dorsal foot TcPO2（48.46±3.46）,dorsal foot artery flow velocity（18.65±5.10 cm/s）,and dorsal foot artery diameter（0.18±0.05 cm,all P<0.05）.Ulcer dimensions（length 2.62±0.36 cm,width 1.85±0.33 cm）and proportion of fresh granulation tissue（87.23%）were also superior in the observation group（all P<0.05）.Both groups experienced significant improvements in skin oxygen pressure,skin temperature,and ankle-brachial index,with more pronounced effects observed in the observation group（P<0.05）.Additionally,post-treatment levels of interleukin-6（IL-6）（8.79±1.35 ng/L）,neutrophils（7.92±1.33109/L）,and high-sensitivity C-reactive protein（Hs-CRP）（1.72±0.36 mg/L）were significantly lower in the observation group（P<0.05）.There was no significant difference in adverse reactions between the two groups（P>0.05）.Conclusion The combination of silver ion gel and hyperbaric oxygen therapy is highly effective for diabetic foot ulcers,improving lower limb microcirculation and hemodynamics,promoting ulcer healing,reducing inflammatory responses,and presenting minimal adverse effects.It is worthy of wider clinical application.
李振堂, 陈卓, 谢天. 含银离子凝胶联合高压氧治疗在糖尿病足部溃疡患者中的治疗效果[J]. 哈尔滨医药, 2025, 45(2): 26-29.
Li Zhentang, Chen Zhuo, Xie Tian. Efficacy of Silver Ion Gel Combined with Hyperbaric Oxygen Therapy in Patients with Diabetic Foot Ulcers. journal1, 2025, 45(2): 26-29.
2025, Vol. 45 
