戊酸雌二醇预处理对绝经后女性取环术宫颈-内膜容受性与阴道微生态的影响研究

doi:10.3969/j.issn.1001-8131.2026.04.007

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摘要目的研究戊酸雌二醇预处理对绝经后女性取环术宫颈-内膜容受性、阴道微生态的影响。方法选取该院2021年1月至2025年12月收治的200例需进行取环术的绝经后女性患者做临床研究对象,通过随机数字表法分组,对照组100例患者术前不使用药物进行干预,观察组的100例患者在术前使用戊酸雌二醇预处理。对比两组临床效果、取环成功率、宫颈-内膜容受性、阴道微生态等指标情况。结果观察组宫颈管长度、PI、RI低于对照组,宫颈内口扩张度高于对照组（P<0.05）。观察组子宫内膜厚度、容积以及VI、FI、VFI均高于对照组（P<0.05）。观察组pH、IL-6、TNF-α均低于对照组,阴道乳酸杆菌相对丰度高于对照组（P<0.05）。观察组手术时间、术中出血量低于对照组（P<0.05）。观察组与对照组取环成功率对比,97.00%高于78.00%（P<0.05）。观察组与对照组并发症发生率对比,3.00%低于20.00%（P<0.05）。结论绝经后女性患者取环术前使用戊酸雌二醇预处理后,可有效提高手术成功率,改善其宫颈内膜的容受性,改善阴道微生态的平衡,具有较高的临床应用价值。

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	孙红先

关键词 ：绝经后女性取环术, 戊酸雌二醇, 宫颈-内膜容受性, 阴道微生态

Abstract：Objective To investigate the effects of estradiol valerate pretreatment on cervical endometrial receptivity and vaginal microbiota in postmenopausal women undergoing intrauterine device(IUD)removal. Methods A total of 200 postmenopausal women requiring IUD removal admitted to our hospital from January 2021 to December 2025 were selected as clinical subjects.They were randomly divided into groups using a random number table.The control group(n=100) received no preoperative drug intervention,while the observation group(n=100) received estradiol valerate pretreatment.Clinical outcomes,IUD removal success rate,cervical endometrial receptivity,and vaginal microbiota were compared between the two groups. Results The observation group showed shorter cervical canal length,lower PI and RI,and higher cervical os dilation compared to the control group(P<0.05).The observation group also exhibited thicker endometrial thickness,larger endometrial volume,and higher VI,FI,and VFI(P<0.05).The observation group had lower pH,IL-6,and TNF-α levels,as well as higher relative abundance of Lactobacillus vaginalis(P<0.05).The observation group required shorter surgical time and had less intraoperative bleeding(P<0.05).The IUD removal success rate in the observation group was 97.00%,significantly higher than that in the control group(P<0.05).The complication rate in the observation group was 3.00%,significantly lower than that in the control group(P<0.05). Conclusion Estradiol valerate pretreatment before IUD removal in postmenopausal women can effectively improve surgical success rates,enhance cervical endometrial receptivity,and restore vaginal microbiota balance,demonstrating favorable clinical outcomes and high application value.It has high clinical application value.

Key words： Postmenopausal women IUD removal Estradiol valerate Cervical-endometrial receptivity Vaginal microbiota

收稿日期: 2026-04-01

PACS:

R711.74

引用本文:

孙红先. 戊酸雌二醇预处理对绝经后女性取环术宫颈-内膜容受性与阴道微生态的影响研究[J]. 哈尔滨医药, 2026, 46(4): 20-22.
Sun Hongxian. Effects of Estradiol Valerate Pretreatment on Cervical Endometrial Receptivity and Vaginal Microecology in Postmenopausal Women undergoing Cervical Cerclage. journal1, 2026, 46(4): 20-22.

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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2026.04.007 或 http://www.hrbyybjb.org.cn/CN/Y2026/V46/I4/20

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[2] 池雅珍. 雌二醇凝胶联合米索前列醇在绝经后妇女取环术中的临床效果分析[J].中外医疗,2024,43(15):82-85.
[3] 陈银萍,张生枝,陈桂丽,等.雌激素替代疗法在围绝经期综合征中的应用效果研究[J].中国妇幼保健,2024,39(24):4996-5000.
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[8] 陈少芬,蒋彦,郑艳霞.米索前列醇片在绝经后取环宫颈预处理中的应用效果分析[J].婚育与健康,2025,31(17):85-87.
[9] 白晓燕,张凌云,金洁琼,等.戊酸雌二醇、来曲唑及黄体酮联合治疗PCOS不孕症疗效及对患者子宫内膜厚度、激素水平和妊娠结局的影响[J].中国计划生育学杂志,2025,33(8):1705-1710.
[10] 周萍,成燕,赵荣,等.戊酸雌二醇联合米索前列醇在绝经后妇女宫内节育器取出中的应用[J].中国计划生育和妇产科,2015(1):70-72.
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[12] 邢媛. 米索前列醇联合戊酸雌二醇对绝经期女性取环成功率的影响研究[J].科技与健康,2024,3(24):48-51.