Abstract：Objective To study the relationship between the level of immunoglobulin and diabetic nephropathy.Methods 121 cases of diabetic patients were selected.All patients underwent glomerular filtration rate（EGFR）,and EGFR>90ml/（min·1.73m2）were included in the normal renal function group（n=28）,patients with 60ml /（min·1.73m2）<EGFR≤90ml /（min·1.73m2）were included in the mild abnormal renal function group（n=32）,and 30ml /（min·1.73m2）<EGFR Patients with EGFR≤30ml /（min·1.73m2）were included in moderate abnormal renal function group（n=31）,and patients with EGFR≤30ml/（min·1.73m2）were included in severe abnormal renal function group（n=30）.The levels of serum immunoglobulin A（IGA）,immunoglobulin M（IgM）and immunoglobulin G（IgG）were detected in all patients.The levels of serum IgA,IgM and IgG in the four groups were compared.The correlation between serum immunoglobulin levels and diabetic nephropathy was analyzed by bivariate Pearson correlation analysis.Results The levels of IgA,IgM and IgG in severe abnormal renal function group were the highest,followed by moderate abnormal renal function group and mild abnormal renal function group,and the lowest in normal renal function group（P<0.05）;by bivariate Pearson correlation test,serum IgA,IgM,IgG levels were positively correlated with EGFR levels（r>0,P<0.05）.Conclusion Serum IgA,IgM and IgG levels are closely related to diabetic nephropathy,which can be used as sensitive indicators for clinical prediction of diabetic nephropathy.
2022, Vol. 42 
