Abstract：Prediabetes is a critical stage in the development of diabetes,characterized by insulin resistance and metabolic disorders.Recent studies have found that the imbalance of gut microbiota is closely related to this condition.Berberine,as a potential bioactive component,has shown effects in regulating gut microbiota and improving metabolic disorders,thus attracting widespread attention.At the same time,tryptophan metabolism also plays an important role in the occurrence and development of diabetes.This article aims to comprehensively explore the application of berberine in patients with prediabetes,focusing on its impact on gut microbiota and tryptophan metabolism,in order to provide theoretical basis and new treatment ideas for clinical practice.Through a comprehensive analysis of existing literature,we will elucidate the value of berberine in regulating gut microbiota balance,improving metabolic abnormalities,and its potential clinical application value,providing new perspectives for the prevention and treatment of prediabetes.
田苗. 黄连素对糖尿病前期肠道菌群及色氨酸代谢调控作用的研究进展[J]. 哈尔滨医药, 2025, 45(1): 127-130.
Tian Miao. Research Progress on the Regulatory Effects of Berberine on Gut Microbiota and Tryptophan Metabolism in Prediabetes. journal1, 2025, 45(1): 127-130.
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