Abstract：Objective Investigating the efficacy of cetirizine hydrochloride combined with ultraviolet therapy in treating uremic pruritus and its impact on IL-31 levels. Methods A total of 100 patients with uremic pruritus treated at our hospital from August were enrolled and randomly divided into two groups(50 cases each)based on admission number parity.The control group received cetirizine hydrochloride monotherapy combined with phototherapy,while the treatment group underwent additional narrowband UVB therapy.The study compared clinical efficacy,laboratory parameters,pruritus severity,sleep quality,and adverse reactions between the two groups. Results The treatment group demonstrated significantly higher overall efficacyvs control,（P<0.05).Post-treatment laboratory results revealed markedly lower levels in the treatment group for serum calcium(Ca),phosphorus(P),5-HT,PTH,β2-MG,CRP,TNF-α,and IL-3 compared to controls(all P<0.05).Significant improvements were observed in pruritus and sleep parameters,with the treatment group showing lower scores than controls in VAS,FIIQand PSQI(all P<0.05).No statistically significant difference in adverse reactions was noted between groups(P>0.05). Conclusion The combination of cetirizine hydrochloride and narrowband UVB phototherapy demonstrates significant clinical benefits for uremic pruritus patients,effectively alleviating symptoms,reducing inflammatory markers,relieving itching,and improving sleep quality with favorable safety,indicating substantial clinical application value.
何岩岩, 刘书真, 王永丽. 盐酸西替利嗪联合紫外线疗法治疗尿毒症皮肤瘙痒的疗效及对IL-31水平的影响[J]. 哈尔滨医药, 2026, 46(1): 34-37.
He Yanyan, Liu Shuzhen, Wang Yongli. The Efficacy of Cetirizine Hydrochloride Combined with Ultraviolet Therapy in Treating Uremic Pruritus and Its Impact on IL-31 Levels. journal1, 2026, 46(1): 34-37.
2026, Vol. 46 
