LNG-IUS与地屈孕酮对子宫内膜息肉患者宫腔镜电切术后临床症状、性激素及复发率的影响

doi:10.3969/j.issn.1001-8131.2026.01.013

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摘要目的观察左炔诺孕酮宫内缓释系统（LNG-IUS）与地屈孕酮对子宫内膜息肉（EP）患者宫腔镜电切术后临床症状、性激素及复发率的影响。方法选取90例EP患者,均行宫腔镜电切术治疗,以随机数表法分为对照组（术后口服地屈孕酮治疗）和观察组（术后置入LNG-IUS治疗）,各45例,观察两组临床症状、子宫内膜厚度、性激素、全身不良反应及复发率。结果治疗后,观察组月经量、月经天数少于对照组,子宫内膜厚度低于对照组（P<0.05）;观察组血清促黄体生成激素（LH）、雌二醇（E2）、孕酮（P）及卵泡刺激素（FSH）水平均低于对照组（P<0.05）;两组全身不良反应发生率相近（P>0.05）;观察组复发率低于对照组（P<0.05）。结论较之于地屈孕酮,宫腔镜电切术后应用LNG-IUS更能有效改善EP患者临床症状、下调相关性激素水平并降低复发率,且未明显增加全身不良反应风险。

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关键词 ：子宫内膜息肉, LNG-IUS, 地屈孕酮, 宫腔镜电切术, 临床症状, 性激素, 复发率

Abstract：Objective To observe the effects of levonorgestrel-releasing intrauterine system(LNG-IUS)and dydrogesterone on clinical symptoms,sex hormone levels and recurrence rate in patients with endometrial polyps(EP)after transcervical resection of endometrial polyps(TCRP). Methods A total of 90 EP patients admitted to our hospital from August,all of whom underwent TCRP.They were divided into the control group(treated with oral dydrogesterone after surgery)and the observation group(treated with postoperative LNG-IUS placement)by random number table method,with 45 cases in each group.The clinical symptoms,endometrial thickness,sex hormone levels,systemic adverse reactions and recurrence rate were observed and compared between the two groups. Results After treatment,the menstrual volume and menstrual days in the observation group were less than those in the control group,and the endometrial thickness was lower than that in the control group(P<0.05).The serum levels of luteinizing hormone(LH),estradiol(E2),progesterone(P)and follicle-stimulating hormone(FSH)in the observation group were all lower than those in the control group(P<0.05). Conclusion There was no significant difference in the incidence of systemic adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).

Key words： Endometrial Polyps LNG-IUS Dydrogesterone Transcervical Resection of Endometrial Polyps(TCRP) Clinical Symptoms Sex Hormones Recurrence Rate

收稿日期: 2026-02-06

PACS:

R711.32

引用本文:

陈荣. LNG-IUS与地屈孕酮对子宫内膜息肉患者宫腔镜电切术后临床症状、性激素及复发率的影响[J]. 哈尔滨医药, 2026, 46(1): 45-47.
Chen Rong. Effects of LNG-IUS and Dydrogesterone on Clinical Symptoms,Sex Hormones and Recurrence Rate in Patients with Endometrial Polyps after Transcervical Resection of Endometrial Polyps. journal1, 2026, 46(1): 45-47.

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