A Study on the Long-term Effects and Related Factors of Adjuvant Chemotherapy after Surgery in Patients with Stage IB-IIA Cervical Cancer and Recurrence Risk Factors
Zhou Tong, Dong Guoling, Ma Qimin
Department of Gynecology, Anyang Maternal and Child Health Hospital Anyang, Henan 455000
Abstract：Objective To investigate the long-term efficacy of adjuvant chemotherapy after surgery in patients with stage IB-IIA cervical cancer and potential risk factors for recurrence,and to analyze the prognostic factors. Methods A retrospective analysis was conducted on the data of 162 patients with stage IB-IIA cervical cancer and potential risk factors for recurrence admitted to our hospital from January 2019 to January 2022.All patients underwent radical hysterectomy.Patients were divided into a chemotherapy group(n=89) and a control group(n=73) based on whether they received adjuvant chemotherapy after surgery.The chemotherapy group received adjuvant chemotherapy with paclitaxel combined with cisplatin,while the control group received only routine follow-up.A 3-year follow-up was conducted,and the progression-free survival(PFS) rate and overall survival(OS) rate of the two groups were recorded in detail.Logistic regression analysis was used to explore the relevant factors affecting the long-term prognosis of the patients. Results After 3 years of follow-up,the PFS rate in the chemotherapy group was 84.27%(75/89),and the OS rate was 87.60%(78/89),while the PFS rate in the control group was 63.01%(46/73),and the OS rate was 75.34%(55/73).The 3-year PFS and OS rates in the chemotherapy group were significantly higher than those in the control group(P<0.05).Poorly differentiated tumors,lymph node metastasis,vascular invasion,and tumor diameter≥4cm were risk factors affecting the 3-year PFS and OS rates(P<0.05),while adjuvant chemotherapy after surgery was a protective factor. Conclusion For patients with stage IB-IIA cervical cancer and recurrence risk factors,adjuvant chemotherapy after surgery can significantly improve their long-term PFS and OS rates and improve prognosis.Furthermore,poor tumor differentiation,lymph node metastasis,vascular invasion,and tumor diameter affect the long-term prognosis of patients.
周彤, 董国玲, 马启敏. 存在复发危险因素ⅠB~ⅡA期宫颈癌患者术后辅助化疗的远期效果及相关因素研究[J]. 哈尔滨医药, 2026, 46(4): 23-26.
Zhou Tong, Dong Guoling, Ma Qimin. A Study on the Long-term Effects and Related Factors of Adjuvant Chemotherapy after Surgery in Patients with Stage IB-IIA Cervical Cancer and Recurrence Risk Factors. journal1, 2026, 46(4): 23-26.
2026, Vol. 46 
