Analysis of the Efficacy and Efficiency of Intermittent Positive Pressure Ventilation Combined with Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome
Chen Tiantian
Luohe Third People's Hospital NICU , Luohe 462300, China
Abstract：Objective To investigate and analyze the therapeutic effect of nasal synchronous positive intermittent pressure ventilation（NSIPPV）combined with pulmonary surfactant（PS）on neonates with respiratory distress syndrome（NRDS）. Methods 96 neonates with NRDS who were treatedwere randomly divided into two groups by computer numerical table.The control group was treated with NSIPPV, and the observation group was treated with PS on this basis.The clinical efficacy and complications, blood gas analysis indexes before and after treatment and various treatment indexes of the two groups were compared. Results The effective rate of the observation group was 93.75%, which was significantly higher than that of the control group（77.08%, P< 0.05）; The incidence of complications such as pulmonary hemorrhage, ventilator-associated pneumonia, pneumothorax, arrhythmia and retinopathy in the observation group was significantly lower than that in the control group（P< 0.05）; After treatment, PaO2, SaO2 and OI in the observation group were higher than those in the control group, while PaCO2 was lower than that in the control group（P< 0.05）; The time of oxygen therapy, the time of symptom disappearance, the time of hospitalization and the rate of tracheal intubation in the observation group were less than those in the control group（P< 0.05）. Conclusion The therapeutic effect of NSIPPV combined with PS on NRDS neonates is significant, which can effectively improve the blood gas analysis indicators, speed up the remission of the disease, reduce the rate of tracheal intubation and complications, and help improve the prognosis.It has important clinical significance.
陈田田. 间歇正压通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征疗效及有效率分析[J]. 哈尔滨医药, 2023, 43(6): 38-40.
Chen Tiantian. Analysis of the Efficacy and Efficiency of Intermittent Positive Pressure Ventilation Combined with Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome. journal1, 2023, 43(6): 38-40.
2023, Vol. 43 
