Abstract:Objective To explore the clinical effect of microsurgery in the treatment of AIDS virus(HIV)complicated with brain tumors. Methods 60 patients with HIV and brain tumor were randomly divided into two groups with 30 cases each.The control group was treated with traditional craniotomy,and the observation group was treated with microsurgery.Compare the treatment effect of the two groups. Results The total effective rate of the observation group was higher than that of the control group.The score of the National Institutes of Health Stroke Scale(NIHSS)[(9.76±1.23)] was lower than that of the control group[(11.31±1.45)],and the score of Barthel Index(BI)[(78.79±7.45)] was higher than that of the control group [(70.54±7.23)],with statistical difference(P<0.05);Postoperative tumor necrosis factor in observation group- α(TNF- α)[(5.14±1.05)ng/L],interleukin-6(IL-6)[(24.56±3.25)ng/L] and central nervous system specific protein(S100 β)[(8.14±1.13)mg/L] level and complication rate [6.67%(2/30)] were lower than those in the control group [(7.58±1.12)ng/L,(28.79±3.32)ng/L,(12.34±2.05)mg/L,26.67%(8/30)],with statistical difference(P<0.05). Conclusion Microsurgery can improve the treatment effect of HIV patients with brain tumors,reduce the neurological damage,speed up the normalization of serological indicators,and have fewer complications.