Application Value Analysis of Somatostatin Combined with Esomeprazole in the Treatment of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding
Gou Xi, Yang Jing, Liu Min
Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China
Abstract：Objective This study aims to observe the clinical efficacy of the combined therapy with the two drugs. Methods All patients were randomLy divided into two groups:52 patients were treated with esomeprazole alone(control group),and 53 patients were treated with somatostatin combined with esomeprazole(observation group).The clinical efficacy,coagulation function and liver function levels were compared between the two groups. Results The overall clinical efficacy and clinical effective rate were both superior in the observation group(Z=-5.057, P=0.000;χ2=7.244, P=0.008).After treatment,the fibrinogen(Fib)level was elevated,while prothrombin time(PT)and activated partial thromboplastin time(APTT)were significantly decreased in both groups compared with those before treatment(P<0.05),and the improvements in the observation group were more significant(t=5.847, P=0.000;t=-8.337, P=0.000;t=-8.235, P=0.000).The liver function indexes were reduced in both groups after treatment(P<0.05),with more prominent improvements in the observation group(t=-13.564, P=0.000;t=-8.228, P=0.000;t=-12.841, P=0.000). Conclusion Somatostatin combined with esomeprazole can achieve satisfactory hemostatic effect,improve the coagulation function and liver function of patients,with favorable clinical efficacy,which is worthy of clinical promotion and application.
勾熙, 杨静, 刘敏. 生长抑素联合艾司奥美拉唑治疗肝硬化合并上消化道出血的应用价值分析[J]. 哈尔滨医药, 2026, 46(2): 11-13.
Gou Xi, Yang Jing, Liu Min. Application Value Analysis of Somatostatin Combined with Esomeprazole in the Treatment of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding. journal1, 2026, 46(2): 11-13.
[1] 孙江霞. 生长抑素联合奥曲肽对肝硬化并发上消化道出血患者止血效果及血清学指标的影响[J].罕少疾病杂志,2024,31(1):83-85. [2] 贾国青,李春涛.枯草杆菌二联活菌联合生长抑素对肝硬化并发上消化道出血的治疗效果[J].中国药物经济学,2023,18(3):56-58,62. [3] 杨红梅,周贵生,徐胜国,等.奥曲肽联合生长抑素与奥美拉唑治疗肝硬化并发上消化道出血的临床疗效[J].临床合理用药杂志,2022,15(27):115-118. [4] Chi Q,Lv Z,Song W.Effect of a combination of omeprazole and high-dose proton pump inhibitors on the treatment of patients with liver cirrhosis complicated with upper gastrointestinal hemorrhage[J].Tropical Journal of Pharmaceutical Research,2021,20(10):2143-2148. [5] 郭春柳,李杰,刘跃辉.生长抑素联合艾司奥美拉唑治疗肝硬化合并上消化道出血的临床效果[J].临床合理用药,2025,18(27):59-62. [6] Feng L,Fu J.Somatostatin plus Gastroscopic Administration of Omeprazole for the Treatment of Acute Upper Gast-rointestinal Bleeding:An Exploration of a Promising Alter-native[J].Evidence-Based Complementary and Alternative Medicine,2022,2022:1-4. [7] 中华医学会肝病学分会.肝硬化诊治指南[J].中华肝脏病杂志,2019,27(11):846-865. [8] 朱昆明,吴梅芳,俞钦民.生长抑素与奥曲肽联合奥美拉唑治疗上消化道出血的疗效比较[J].临床合理用药,2024,17(30):74-77. [9] Dias E,Azevedo F,Afonso A,et al.Upper Gastrointestinal Bleeding in a Patient with Liver Cirrhosis:Gastroeso-phageal Varices Are not Always to Blame[J].J Gastroin-testin Liver Dis,2021,30(3):323. [10] 陈琪. 萍生长抑素联合艾司奥美拉唑钠治疗肝硬化上消化道出血的临床效果[J].临床合理用药,2024,17(31):21-25. [11] Eshkiki ZS,Khazaei R,Parsi A,et al.COMPARING THE PREDICTIVE EFFICACY OF MELD AND ALBI SCORES IN LIVER CIRRHOSIS PATIENTS WITH ACUTE UPPER GASTROINTESTINAL BLEEDING[J].Arq Gastroenterol,2025,62:e24075. [12] Svoboda P,Konecny M,Martinek A,et al.Acute upper gastrointestinal bleeding in liver cirrhosis patients[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2012,156(3):266-270. [13] 张莉,吴凤丽.裸花紫珠胶囊结合生长抑素治疗老年肝硬化上消化道出血患者的临床效果[J].河南医学研究,2023,32(16):3023-3026. [14] Wehmeyer MH,Horvatits T,Buchholz A,et al.Stop of proton-pump inhibitor treatment in patients with liver cirrhosis(STOPPIT):study protocol for a prospective,multicentre,controlled,randomized,double-blind trial[J].Trials,2022,23(1):302. [15] El-Azab G.Proton Pump Inhibitors in Patients with Cirrhosis:Pharmacokinetics,Benefits and Drawbacks[J].Curr Gastroenterol Rep,2024,26(12):323-334. [16] Torres-Iglesias R,Mora-Luján JM,Iriarte A,et al.Long-term use of somatostatin analogs for chronic gastroint-estinal bleeding in hereditary hemorrhagic telangiectasia[J].Front Med(Lausanne),2023,10:1146080. [17] 吴海棠,杨维忠,劳方.凝血酶联合生长抑素对消化道出血患者炎性因子、凝血及纤溶效果影响[J].华南预防医学,2023,49(7):858-862. [18] He X,Dai Z,Shi P,et al.Intravenous Drip of Somatostatin Followed by Restricted Fluid Resuscitation to Treat Upper Gastrointestinal Bleeding in Patients with Liver Cirrhosis[J].Evidence-Based Complementary and Alterna-tive Medicine,2021:6548479. [19] 王彬声,魏晓艳,杨帆.探究奥美拉唑联合生长抑素在肝硬化合并上消化道出血治疗中的应用价值[J].系统医学,2025,10(21):74-77. [20] 许永莲. 生长抑素联合奥美拉唑治疗肝硬化上消化道出血的效果与护理分析[J].中国现代药物应用,2025,19(1):92-95.
2026, Vol. 46 
