Abstract：Objective To investigate the effects of high-dose immunoglobulin combined with glucocorticoids on peripheral blood Th17 cell levels in children with immune thrombocytopenia（ITP）.Methods A total of 78 children with ITP who were admitted were enrolled.Using random number table method,they were divided into medium-dose group（routine-dose immunoglobulin and glucocorticoid,n=38） and high-dose group（high-dose immunoglobulin combined with glucocorticoid,n=40）.The clinical effects of the two groups were compared.Changes in levels of peripheral blood helper T cell 17（Th17） and regulatory T cells（Treg） before and after treatment in both groups were observed.Th17/Treg was calculated,and drug safety of the two groups was compared.Results The total effective rate in the high-dose group was significantly higher than that in the middle-dose group（P<0.05）.Compared with the same group before treatment,Th17 and Th17/Treg in the two groups after treatment were obviously decreased,while Treg was significantly increased;however,Th17 and Th17/Treg in the high-dose group after treatment were significantly lower than those in the middle-dose group,while Treg was significantly higher than that in the middle-dose group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups [17.50%（7/40） vs 10.53%（4/38）]（χ2=0.782,P>0.05）.Conclusion High dose immunoglobulin combined with glucocorticoid in the treatment of immune thrombocytopenia has a significant clinical effect and high safety,which can effectively change the content of Th17 and Treg,regulate the balance of Th17/Treg cells.
黄小龙. 不同剂量人免疫球蛋白联合糖皮质激素治疗免疫性血小板减少症对患儿外周血Th17细胞水平的影响[J]. 哈尔滨医药, 2021, 41(1): 3-5.
Huang Xiaolong. Influence of High-Dose Immunoglobulin Combined With Glucocorticoids on Peripheral blood Th17 Cell Levels in Children With Immune Thrombocytopenia. journal1, 2021, 41(1): 3-5.
2021, Vol. 41 
