Abstract：Objective To study the diagnostic efficacy and analyze the missed diagnosis factors of colposcopy cervical biopsy in cervical precancerous lesions. Methods A total of 318 patients who were transferred for colposcopy due to abnormal cervical cancer screening were prospectively enrolled as subjects.Localized biopsies of 4 biopsy sites of the cervix were performed for each patient under colposcope（including targeted biopsy and random biopsy in the lesion or suspected lesion area）in order to evaluate the diagnostic efficacy of targeted and random biopsy for cervical precancerous lesions. Results Among the 318 patients,173（54.40%,173/318）were pathologically diagnosed with CIN II+,and 168（97.11%,166/173）were detected by colposcopy targeted biopsy with CIN II+.The sensitivity of colposcopy result with G2 as the threshold was lower than that with G1（71.43% and 97.11% respectively）.Randomized biopsy sites can increase the detection rate of targeted biopsies（P<0.05）.The detection rate of 1 biopsy site was lower than that of multiple biopsy sites（diagnostic sensitivity of 1,2,4 and 4 biopsy sites were 80.35%,97.69%,100.0%,100.0%,respectively）. Conclusion Colposcopy cervical biopsy has good diagnostic efficacy for cervical precancerous lesions.Incremental effect can be achieved through targeted biopsy and multiple biopsies during biopsy,and better diagnostic efficacy can be obtained by combining the results of cervical cancer screening and colposcopy diagnosis.
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2022, Vol. 42 
