The Effect of Hyperbaric Oxygen in Obstructive Sleep Apnea Hypopnea Syndrome：a Meta-Analysis
Huang Ping1, Yang Hao1, Liu Hanyun2, Li Yuhong2
1. Graduate School of Qinghai University,Qinghai 810000,China; 2. Department of Respiratory Medicine,Affiliated Hospital of Qinghai University,Qinghai 810000,China
Abstract：Objective To evaluate the efficacy of hyperbaric oxygen in patients with OSAHS.Methods PubMed,Embase,Web of science,Cochran Library,CNKI,VIP,Wanfang and China Biomedical Literature Database were searched to collect randomized controlled trials of hyperbaric oxygen in treatment of obstructive sleep apnea hypopnea syndrome from inception to March 2021.Two researchers independently completed the literature screening,data extraction and quality evaluation of the included literature.RevMan5.4 software and Stata16.0 software were used to perform meta-analysis.Results A total of 6 RCTs involving 512 patients were included.The results of meta-analysis showed that hyperbaric oxygen in improving AHI（SMD=-2.05,95%CI[-2.88~-1.22],P<0.00001）,SaO2（MD=7.49,95%CI[5.65~9.33],P<0.00001）,the longest apnea time（MD=-4.31,95%CI[-4.95~-3.67],P<0.00001）,snoring（RR=0.21,95%CI[0.06~0.71],P=0.01）,daytime drowsiness（RR=0.10,95%CI [0.01~0.76],P=0.03）and nocturnal awakening（RR=0.19,95%CI [0.05~0.68],P=0.01）and other effects was better than the control group,and the difference was statistical significance.Conclusion The therapeutic effect of hyperbaric oxygen in patients with OSAHS is definite.However,due to the small number of included literature,large heterogeneity and all from Chinese literature,so more studies are needed to prove the efficacy of HBOT on OSAHS.
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2023, Vol. 43 
