Research Progress on the Immunoregulatory Role of CD155 in Malignant Tumors
Liu Xue1, Guo Lingchuan2
1. Department of Oncology,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China; 2. Department of Pathology,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China
Abstract：CD155,a glycoprotein of immunoglobulin superfamily,is up-regulated in a variety of malignant tumor cells and associated with patient prognosis.Recently,the immunoregulatory role of CD155 has attracted extensive attention in tumors.CD155 could interact with co-stimulatory receptors（CD226）and co-inhibitory receptors（TIGIT and CD96）,regulating function of tumor infiltrating lymphocytes.Immunotherapy of targeting CD155 signaling is expected to improve the prognosis of tumor patients and has great potential for clinical application.This article will review the research progress of CD155 from the aspects of the relationship between CD155 and the prognosis of malignant tumor patients,immunoregulatory role and related immunotherapy.
刘雪, 郭凌川. CD155在恶性肿瘤中的免疫调控作用研究进展[J]. 哈尔滨医药, 2023, 43(2): 127-129.
Liu Xue, Guo Lingchuan. Research Progress on the Immunoregulatory Role of CD155 in Malignant Tumors. journal1, 2023, 43(2): 127-129.
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2023, Vol. 43 
