Significance of Combined Detection of Serum Carcinoembryonic Antigen and CA125 in Cervical Cancer and its Relationship with High Risk Factors
Zhou Pingle1, Zuo Liang2
1. Department of Obstetrics and Gynecology,Liqun Hospital,Putuo District,Shanghai 200331,China; 2. Department of Surgery,Shanghai Putuo District People's Hospital;Shanghai 200333,China
Abstract：Objective The aim of this study was to investigate the significance of serum carcinoembryonic antigen（CEA）and carbohydrate antigen 125（CA125）in cervical cancer and its relationship with high risk factors,and to provide reference for the clinical diagnosis of cervical cancer.Methods 110 cases of cervical cancer patients were selected as the observation group,and 100 healthy women were selected as the control group in the same period.The venous blood was taken from the fasting morning and the serum was collected by centrifugation.The CEA and CA125 of the two groups was measured by the electrochemical luminescence method.The accuracy,sensitivity and specificity of CEA combined with CA125 in the diagnosis of cervical cancer were analyzed by comparing the positive rate of serum CEA and CA125 in the observation group according to the clinical stage.In addition,Test（HC-II）was used to determine human papillomavirus（HPV）infection in both groups.Results The levels of serum CA125 and CEA in the patients with cervical cancer were（43.29±16.82）U/mL and（25.19±21.36）ng/mL respectively,which were significantly higher than those in the control group.The positive rate of CEA and CA125 in cervical cancer patients（P<0.05）.The difference of CEA and CA125 between the two groups was statistically significant（P<0.05）,and the stage Ⅲ and Ⅳ were significantly higher than those of stage Ⅰ and stage Ⅱ.The accuracy and sensitivity of CEA combined with CA125 in the diagnosis of cervical cancer were significantly higher than those of CEA or CA125 alone（P<0.05）.There was no significant difference in the specificity of CEA,CA125 or CEA combined with CA125 in the diagnosis of cervical cancer（P>0.05）.The positive rate of HPV infection in patients with cervical cancer was 100%,which was significantly higher than that in healthy controls（P<0.05）.Patients with HPV positive infection and serum CEA and CA125 content of the same trend,the relationship is closely related.Conclusion EA combined with CA125 has a good sensitivity,accuracy and specificity in the diagnosis of cervical cancer,and is highly correlated with HPV infection in patients with high clinical value.
周平乐, 左亮. 血清癌胚抗原及CA125联合检测在宫颈癌中意义及其与高危因素的关系[J]. 哈尔滨医药, 2023, 43(3): 27-29.
Zhou Pingle, Zuo Liang. Significance of Combined Detection of Serum Carcinoembryonic Antigen and CA125 in Cervical Cancer and its Relationship with High Risk Factors. journal1, 2023, 43(3): 27-29.
[1] Ratanatharathorn V,Powers W E,Steverson N,et al.Bone metastasis from cervical cancer[J].Cancer,2015,73(9):2372-2379. [2] Takeda N,Sakuragi N,Takeda M,et al.Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy[J].ActaObstetriciaEtGynecologicaScandinavica,2015,81(12):1144-1151. [3] 姚有娣,程易凡,王丹凤,等.宫颈液基薄层细胞学检测与人乳头瘤病毒检测对宫颈癌诊断的效用评价[J].中国性科学,2016,25(2):44-47. [4] 周炳辉,张春访.宫颈癌患者血清SCC、CYFRA21-1、CA125、CEA联合检测的临床意义[J].现代中西医结合杂志,2014,23(13):1453-1454. [5] 尹红章,章莲蓬.宫颈癌患者血清 CYFRA21-1、TPS、CA125和 CEA 表达的临床分析[J].现代肿瘤医学,2015,23(20):3018-3020. [6] 王若琪,韩菲菲.CA125、CA153、CA199和SCC联合检测对宫颈癌的诊断价值[J].实用癌症杂志,2016,31(11):1744-1746. [7] 王力. 高危型HPV宫颈癌宫颈活检及宫颈脱落细胞病理检查结果分析[J].检验医学与临床,2015,12(23):3591-3592. [8] Dasari S,Wudayagiri R,Valluru L.Cervical cancer:Biomarkers for diagnosis and treatment[J].ClinicaChimicaActa,2015,445(26):7-11. [9] 王艳丽,李国文,韩新巍.中晚期宫颈癌治疗研究进展[J].中国卫生标准管理,2016,7(01):29-32. [10] Roomi M W,Kalinovsky T,Cha J,et al.Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice[J].Experimental & Therapeutic Medicine,2015,9(2):294-302.
2023, Vol. 43 
