|
|
|
| Study on Serum FGF-23 and ADP Levels in Predicting Premature Delivery in Patients with Gestational Diabetes Mellitus |
| Yang Yaqi |
| Department of Obstetrics and Gynecology,Henan Southwest Branch,Henan Provincial People's Hospital Pingdingshan 467000 |
|
|
|
|
Abstract Objective To analyze the value of serum fibroblast growth factor-23（FGF-23）and adiponectin（ADP）levels in predicting premature delivery in patients with gestational diabetes mellitus. Methods 70 patients with gestational diabetes mellitus in our hospital were prospectively selected as the research objects.They were followed up to delivery,and the incidence of premature birth was counted.A general information questionnaire was designed to inquire and record the general information of the patients and the laboratory indexes [serum triglyceride（TG）,total cholesterol（TC）,total cholesterol（TC）] at the time of diagnosis of gestational diabetes mellitus Fasting blood glucose（FPG）,FGF-23,ADP],to analyze the value of serum FGF-23,ADP levels in predicting premature delivery in patients with gestational diabetes mellitus. Results There were 17 cases of premature delivery and 53 cases of no premature delivery in 70 cases of gestational diabetes mellitus;The level of serum FGF-23 in the occurrence group was higher than that in the non occurrence group,and the level of serum ADP was lower than that in the non occurrence group（P<0.05）;Multivariate logistic regression analysis showed that high serum FGF-23 level and low ADP level were associated with premature delivery in patients with gestational diabetes mellitus（P<0.05）;The receiver operating characteristic curve（ROC）was drawn.The results showed that the area under the curve（AUC）of serum FGF-23,ADP levels and combined detection in predicting premature delivery in patients with gestational diabetes mellitus was more than 0.7,and the value of combined diagnosis was the best. Conclusion The serum levels of FGF-23 and ADP have higher value in predicting premature delivery in patients with gestational diabetes mellitus.
|
|
Received: 08 May 2022
|
|
|
|
|
|
[1] 隽娟,孙祎赢,叶彩云,等.妊娠期糖尿病合并慢性高血压孕妇胰岛素抵抗水平及其对妊娠结局的影响[J].中华围产医学杂志,2020,23(2):91-97.
[2] 吴霞,吴学厅,黄磊涛,等.脂联素防治糖尿病心肌病的研究进展[J].中国临床医学,2019,26(1):145-150.
[3] 左帆,张旭祥,吴斌,等.妊娠期糖尿病患者血清NRG4、FGF-23、PGRN水平及其临床意义[J].现代生物医学进展,2020,20(20):3961-3964.
[4] 谯玲. 围产期早期保健及营养指导对妊娠期糖尿病及早产的预防价值[J].医学临床研究,2019,36(6):1100-1102,1105.
[5] 薛燕妮,魏威.高龄产妇妊娠期糖尿病发病情况及相关影响因素分析[J].中国妇幼保健,2019,34(1):50-53.
[6] 雷婷,王海宁,昝丽娜,等.胱抑素C、IL-17A和FGF-23在2型糖尿病肾病患者血清中的表达及临床意义[J].医学临床研究,2019,36(9):1789-1790.
[7] 黄丽君,占志平,张琳静,等.血清FGF-21、FGF-23在糖尿病肾病中的表达及其临床意义[J].标记免疫分析与临床,2020,27(4):598-602.
[8] 张计划,吴燕,徐萌.糖尿病肾病严重程度与尿脂联素的相关性及临床意义[J].海南医学,2018,29(7):926-929.
[9] 陈莉,周正平.HbA1c、Hcy和ADP在妊娠期糖尿病筛查中的临床意义[J].检验医学与临床,2018,15(11):1688-1691.
[10] 叶燕珍,杜建玲.成纤维细胞生长因子在糖尿病中的作用[J].国际内分泌代谢杂志,2018,38(3):200-203,212. |
| [1] |
Zhou Xiaopei. Effect of Colostrum Oral Immunotherapy Combined with Probiotics on Gastrointestinal Function and Intestinal Flora in Premature Infants[J]. journal1, 2023, 43(3): 38-40. |
| [2] |
Lv Rui. The Value of Composite Index A-aDO2,a/A Ratio and PaO2 /FiO2 in Predicting Respiratory Distress with Respiratory Failure in Late Preterm Infants[J]. journal1, 2023, 43(3): 41-42. |
| [3] |
. [J]. journal1, 2023, 43(3): 88-89. |
| [4] |
. [J]. journal1, 2023, 43(2): 66-67. |
| [5] |
. [J]. journal1, 2023, 43(2): 78-80. |
| [6] |
Ding Yarui. Relationship Between Serum VEGF and Hcy Expression and Macrosomia in Gestational Diabetes Mellitus[J]. journal1, 2023, 43(1): 36-37. |
|
|
|
|
2023, Vol. 43 
