脂质与糖尿病视网膜病变因果关系的孟德尔随机化分析

doi:10.3969/j.issn.1001-8131.2024.04.011

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Abstract Objective To investigate the bidirectional causal relationship between lipid and diabetic retinopathy（DR）.Methods Data of genome-wide association study on lipid and DR were collected.The bidirectional Mendelian randomization（MR）of two samples was performed by inverse variance weighted method,MR-Egger regression method and weighted median method.Cochran's Q test was used to check the heterogeneity of the results and the MR-Egger regression method to evaluate of the results.Results The results of inverse variance weighted method showed that phosphatidylethanolamine（16：0_18：2）（OR=0.916,95%CI：0.864~0.971,P=0.003,PFDR=0.174）and triacylglycerol 50：2（OR=0.850,95%CI：0.760~0.952,P=0.005,PFDR=0.174）decreased the risk of DR.The results of reverse MR analysis showed that DR was causally associated with increased diglycerol（16：0_18：2）（OR=1.064,95%CI：1.021~1.109,P=0.003,PFDR=0.194）and triacylglycerol 50：1（OR=1.067,95%CI：1.026~1.109,P=0.001,PFDR=0.194）.The results of various MR methods were basically consistent,and the results of sensitivity analysis showed that the above results were consistent and reliable.Conclusion Phosphatidylethanolamine（16：0_18：2）and triacylglycerol 50：2 have negative causal associations with the risk of DR,while DR has positive causal effects on diglycerol（16：0_18：2）and triacylglycerol 50：1.

Key words： lipid Diabetic retinopathy Mendelian randomization Causal inference

Received: 14 March 2024

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R587.1

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	Wang Xin
	Liu Xinghai

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Wang Xin,Liu Xinghai. A Mendelian Randomization Analysis on the Causal Associations between Lipids and Diabetic Retinopathy[J]. journal1, 2024, 44(4): 37-40.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.04.011 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I4/37

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