血小板抗体、交叉配型与骨髓瘤输注无效相关性研究

doi:10.3969/j.issn.1001-8131.2025.02.011

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Abstract Objective To explore the correlation between platelet antibodies,cross matching results,and ineffective platelet transfusion in patients with multiple myeloma.Method A retrospective analysis was conducted on 124 patients with multiple myeloma.The patients were divided into an effective group and an ineffective group based on whether platelet transfusion was effective.Among them,there were 100 cases in the effective group and 24 cases in the ineffective group.Compare the clinical data,platelet antibodies,and cross matching results of two groups of patients,and analyze the correlation between platelet antibodies,cross matching results,and ineffective platelet transfusion in patients with multiple myeloma,as well as the influencing factors of ineffective platelet transfusion.Result Factor analysis showed that splenomegaly（β=3.524,...）,OR=3.933,95%Cl=7.047-13.397）、 Heat generation（β=1.630,OR=5.102,95%Cl=1.389-18.744）、 Platelet antibody positivity（β=2.114,OR=8.280,95% Cl=2.056-23.340）and cross matching positivity（β=1.548,OR=4.701,95% Cl=1.104-20.016）are both influencing factors for ineffective platelet transfusion in patients.Conclusion Positive platelet antibodies,cross matching,fever,and splenomegaly are independent influencing factors for ineffective platelet transfusion in patients with multiple myeloma.Clinical attention should be paid to patients with multiple myeloma who are accompanied by these influencing factors.

Key words： platelet antibodies Cross matching Multiple myeloma Platelet infusion

Received: 18 February 2025

PACS:

R733.3

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	Articles by authors
	Su Qing
	Fu Lixia
	Chao Ling

Cite this article:

Su Qing,Fu Lixia,Chao Ling. Study on the Correlation between Platelet Antibodies Cross Matching and Ineffectiveness of Myeloma Infusion[J]. journal1, 2025, 45(2): 37-39.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.02.011 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I2/37

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