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| Preparation and Characterization of Carboxylated Graphene Oxide as a Pharmaceutical Carrier |
| Wang Yingqi, Zhao Chengcheng* |
| Heilongjiang University of Traditional Chinese Medicine,Experimental training center,Harbin 150040,China |
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Abstract Objective To explore the potential of graphene oxide as a drug carrier material,prepare functionalized graphene oxide and characterize it,providing an excellent carrier for achieving high drug loading,targeted delivery and controlled release of drugs. Methods Graphene oxide preparation by five-day oxidation method and covalently modified to become carboxylated graphene oxide.Infrared spectroscopy,transmission electron microscopy and other methods were used for characterization. Results The yield of carboxylated graphene oxide was 80.72%,and average particle size is 1510 nm.The sample had a distinct -OH absorption peak at 3393.37cm-1,and carboxyl -C=O peaks at 1732.01cm-1 and 1616.35cm-1,which were the stretching vibration peaks of the carbonyl C=O on the carboxylic acid at the edge of the carboxylated graphene oxide sheet.There was a carboxyl-C-O peak at 1072.42cm-1,which was the stretching vibration peak of C-O on the carboxylic acid at the edge of the carboxylated graphene oxide. Conclusion Compared with graphene oxide,carboxylated graphene oxide contains a larger amount of oxygen-containing functional groups in its structure,which is easy to combine with water molecules to form hydrogen bonds,thus providing an excellent drug carrier for achieving high drug loading,targeted drug delivery and controlled release.
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Received: 22 April 2025
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2025, Vol. 45 
