肝移植术后外周血中性粒细胞/淋巴细胞比值与T细胞介导排斥反应的相关性分析

doi:10.3969/j.issn.1001-8131.2025.06.002

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Abstract Objective To investigate the correlation between neutrophil/lymphocyte ratio in peripheral blood and T cell mediated rejection after liver transplantation. Methods This study enrolled 80 liver transplant recipients.Patients were divided into a rejection group(16 cases)and a non-rejection group(64 cases)based on the occurrence of TCMR.Preoperative,intraoperative,and postoperative clinical data were compared between the two groups.Risk factors for TCMR were analyzed using the Log-rank test and Logistic regression(univariate and multivariate analyses).Pearson correlation was used to assess associations. Results The rejection group exhibited significantly longer operative time,higher Rejection Activity Index(RAI),and elevated postoperative NLR levels.Multivariate Logistic regression identified RAI,NLR on postoperative day 3,NLR on day 5,operative duration,and red blood cell transfusion volume as independent risk factors for TCMR(Figure 2).Among these,NLR on day 1 showed the strongest association.Pearson correlation confirmed a positive correlation between these factors and TCMR risk. Conclusion Prolonged operative time,increased red blood cell transfusion volume,elevated postoperative RAI,and higher NLR values are associated with an increased risk of acute rejection after liver transplantation.These findings highlight the need for clinical monitoring and preventive strategies.

Key words： Liver transplantation Neutrophil-to-lymphocyte ratio(NLR) T cell mediated rejection Correlation

Received: 22 July 2025

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R657.3

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	Articles by authors
	Sun Yibo
	Zhao Yunfeng
	Miao Shuzhai

Cite this article:

Sun Yibo,Zhao Yunfeng,Miao Shuzhai. Correlation Analysis between Neutrophil/lymphocyte Ratio in Peripheral Blood and T cell Mediated Rejection after Liver Transplantation[J]. journal1, 2025, 45(6): 5-9.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.06.002 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I6/5

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