戊酸雌二醇预处理对绝经后女性取环术宫颈-内膜容受性与阴道微生态的影响研究

doi:10.3969/j.issn.1001-8131.2026.04.007

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Abstract Objective To investigate the effects of estradiol valerate pretreatment on cervical endometrial receptivity and vaginal microbiota in postmenopausal women undergoing intrauterine device(IUD)removal. Methods A total of 200 postmenopausal women requiring IUD removal admitted to our hospital from January 2021 to December 2025 were selected as clinical subjects.They were randomly divided into groups using a random number table.The control group(n=100) received no preoperative drug intervention,while the observation group(n=100) received estradiol valerate pretreatment.Clinical outcomes,IUD removal success rate,cervical endometrial receptivity,and vaginal microbiota were compared between the two groups. Results The observation group showed shorter cervical canal length,lower PI and RI,and higher cervical os dilation compared to the control group(P<0.05).The observation group also exhibited thicker endometrial thickness,larger endometrial volume,and higher VI,FI,and VFI(P<0.05).The observation group had lower pH,IL-6,and TNF-α levels,as well as higher relative abundance of Lactobacillus vaginalis(P<0.05).The observation group required shorter surgical time and had less intraoperative bleeding(P<0.05).The IUD removal success rate in the observation group was 97.00%,significantly higher than that in the control group(P<0.05).The complication rate in the observation group was 3.00%,significantly lower than that in the control group(P<0.05). Conclusion Estradiol valerate pretreatment before IUD removal in postmenopausal women can effectively improve surgical success rates,enhance cervical endometrial receptivity,and restore vaginal microbiota balance,demonstrating favorable clinical outcomes and high application value.It has high clinical application value.

Key words： Postmenopausal women IUD removal Estradiol valerate Cervical-endometrial receptivity Vaginal microbiota

Received: 01 April 2026

PACS:

R711.74

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	Sun Hongxian

Cite this article:

Sun Hongxian. Effects of Estradiol Valerate Pretreatment on Cervical Endometrial Receptivity and Vaginal Microecology in Postmenopausal Women undergoing Cervical Cerclage[J]. journal1, 2026, 46(4): 20-22.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.04.007 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I4/20

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