富血小板血浆（PRP）治疗下肢动脉硬化闭塞症Ⅲ期临床研究

doi:10.3969/j.issn.1001-8131.2024.04.006

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Abstract Objective To observe the clinical study of platelet-rich plasma（PRP）for the treatment of lower extremity atherosclerotic occlusive disease stage Ⅲ.Methods 44 patients with lower extremity atherosclerotic occlusive disease who met the inclusion criteria were selected and randomly divided into two groups of 27 cases each.The control group was treated with intravenous Extract of Ginkgo Biloba Leaves injection and Papaverine hydrochloride for injection,and the treatment group was treated with PRP based on the control group.Both groups were treated for 2 weeks,and the clinical efficacy was evaluated by observing the wound healing rate,serum C-reactive protein（CRP）and fibrinogen（FIB）changes before and after treatment.Results The wound healing rate was higher in the treatment group than in the control group（P<0.05）.The reduction of CRP level and FIB level before and after treatment was significantly higher in the treatment group than in the control group（P<0.05）.Conclusion Compared with simple debridement,platelet-rich plasma（PRP）used for the treatment of lower limb atherosclerotic occlusive disease stage Ⅲ can improve the wound healing rate,reduce the inflammatory response,and lower fibrinogen,which has good efficacy in clinical practice.

Key words： platelet-rich plasma lower extremity atherosclerotic occlusive disease wound healing C-reactive protein fibrinogen

Received: 14 March 2024

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R543.1+2

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	Chen Wenge

Cite this article:

Chen Wenge. Clinical Study of Platelet-rich Plasma（PRP）for Lower Extremity Atherosclerotic Occlusive Disease in Stage Ⅱ[J]. journal1, 2024, 44(4): 20-22.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.04.006 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I4/20

[1] 黄浪浪,徐驲,王建安,等.益气活血通脉颗粒治疗下肢动脉硬化闭塞症的临床研究[J].中药药理与临床,2022,38(01):184-187.
[2] 梁新雨,冯夏,高玉杰,等.不同药物治疗下肢动脉硬化闭塞症伴间歇性跛行有效性和安全性的网状Meta分析[J].中国循证医学杂志,2022,22(06):655-666.
[3] Bai J,Wang F,Wang X,et al.Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans[J].PeerJ,2020,8:e9305.
[4] 孙浩博,贾志刚,虞俊杰.3种不同创基准备程序性治疗方法在慢性难愈性创面中的效果观察[J].中国现代医学杂志,2023,33(05):68-73.
[5] Aghaloo T L,Moy P K,Freymiller E G.Investigation of platelet-rich plasma in rabbit cranial defects:A pilot study[J].J Oral Maxillofac Surg,2002,60(10):1176-1181.
[6] Marx R E,Carlson E R,Eichstaedt R M,et al.Platelet-rich plasma:Growth factor enhancement for bone grafts[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,1998,85(6):638-646.
[7] 下肢动脉硬化闭塞症诊治指南[J].中华普通外科学文献(电子版),2016,10(01):1-18.
[8] Martinez-Zapata M J,Marti-Carvajal A J,Sola I,et al.Autologous platelet-rich plasma for treating chronic wounds[J].Cochrane Database Syst Rev,2016,2016(5):D6899.
[9] 赵钢等. 周围血管病基础与临床[M].人民军医出版社,2015.
[10] Pan A,Zhong M,Wu H,et al.Topical Application of Keratinocyte Growth Factor Conjugated Gold Nanoparticles Accelerate Wound Healing[J].Nanomedicine,2018,14(5):1619-1628.
[11] 申一宇,熊武,周建大.慢性难愈性创面的中西医疗法应用及进展[J].湖南中医药大学学报,2022,42(12):2134-2140.
[12] 马秉正,赵而海,王进,等.基于Luminex技术对比分析激活后的脐血和成人富血小板血浆研究[J].中国输血杂志,2023,36(01):11-15.
[13] Everts P,Onishi K,Jayaram P,et al.Platelet-Rich Plasma:New Performance Understandings and Therapeutic Considerations in 2020[J].Int J Mol Sci,2020,21(20).
[14] Wu P I,Diaz R,Borg-Stein J.Platelet-Rich Plasma[J].Phys Med Rehabil Clin N Am,2016,27(4):825-853.
[15] 秦新愿,王江宁.自体富血小板血浆局部注射治疗糖尿病足溃疡的临床研究[J].中国修复重建外科杂志,2019,33(12):1547-1551.
[16] 陈庆庆,何红晨.富血小板血浆促进创面愈合的研究进展[J].中国烧伤创疡杂志,2018,30(01):17-20.
[17] 富文达,李娜,魏华,等.自体富血小板血浆联合负压封闭引流技术治疗慢性难愈性创面疗效的Meta分析[J].中国输血杂志,2023,36(02):155-160.
[18] 曾皓,张烁,徐泽华,等.脂肪干细胞胶联合富血小板血浆治疗难愈性创面的临床效果[J].中国当代医药,2023,30(06):48-51.