入院时NIHSS评分联合血浆Copeptin、D-二聚体对急性缺血性脑卒中患者的病情进展评估价值分析

doi:10.3969/j.issn.1001-8131.2025.01.003

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Abstract Objective To explore the value of National Institutes of Health Stroke Scale（NIHSS）score combined with plasma and peptidogysin（Copeptin）and D-dimer for disease progression in patients with acute ischemic stroke（AIS）. Methods 90 AIS patients were selected for the study.According to the NIHSS score,they were mild into moderate group（15 points,n=67）and severe group（>15 points n=23）,and 40 healthy patients included in the physical examination in the same period were healthy group.Comparing differences in NIHSS scores,plasma Copeptin and D-dimer levels,analyzed the correlation between Copeptin and D-dimer levels and disease progression in AIS patients,binary logistic analyzed the relationship between Copeptin and D-dimer levels and disease progression,and ROC analyzed the value of Copeptin and D-dimer on disease progression in AIS patients. Results NIHSS score and Copeptin and D-dimer levels in AIS and severe group were higher than healthy and mild to moderate groups（P<0.05）;Copeptin,D-dimer levels were positively correlated with disease progression in AIS patients（P<0.05）;Binary logistics regression analysis showed that,Copeptin And D-dimer levels were related factors affecting disease progression in AIS patients（P<0.05）;ROC result display,The AUC of Copeptin and D-dimer evaluation for the disease progression in AIS patients were 0.933 and 0.969,respectively,The AUC for the combined diagnosis was 0.988,A sensitivity of 95.65%,The specificity ratio was 82.09%. Conclusion The plasma levels of Copeptin and D-dimer in AIS patients are high,which are correlated with admission NIHSS score,are the relevant influencing factors of disease progression,and have certain reference value in clinical diagnosis.

Key words： acute ischemic stroke NIHSS score and peptidomin D-dimer disease progression

Received: 15 February 2025

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R743.3

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	Lu Kehong

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Lu Kehong. Evaluation Value Analysis of NIHSS Score Combined with Plasma Copeptin and D-dimer in Patients with Acute Ischemic Stroke[J]. journal1, 2025, 45(1): 8-10.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.01.003 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I1/8

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