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| The Effect of Rocuronium Bromide and Phenylsulfonyl cis Atracurium Anesthesia on Anesthesia Efficacy and Complications in Patients undergoing Cholecystectomy |
| Luo Dan, Li Jin* |
| Department of Anesthesiology,First Affiliated Hospital of Xinjiang Medical University Urumqi,Xinjiang 830000 |
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Abstract Objective To compare the application effects of different muscle relaxants in rapid induction tracheal intubation general anesthesia for cholecystectomy. Methods A total of 54 patients were included in this clinical trial.All patients underwent laparoscopic cholecystectomy(LC) and received general anesthesia with combined muscle relaxants and induction tracheal intubation during the operation.The patients were randomLy divided into two groups,each containing 27 cases,and were respectively designated as the control group and the observation group.The control group was given rocuronium bromide muscle relaxant anesthesia,and the observation group was given cis-atracurium benzenesulfonate muscle relaxant anesthesia.The anesthesia effect and blood flow of the two groups were compared.Dynamic changes[heart rate(HR),mean arterial pressure(MAP)],stress indicators(blood sugar,plasma total cortisol,histamine levels),and complications of anesthesia,etc. Results In terms of the average onset time,maintenance time and recovery time of muscle relaxation,the control group was shorter than the observation group(P<0.05).In terms of hemodynamics,there was no significant fluctuation in HR and MAP levels in the observation group after drug administration compared with before(P>0.05),while in the control group,MAP level decreased and HR level increased after drug administration compared with before,and there was a significant difference between the two groups(P<0.05).There was no significant fluctuation in blood glucose,total plasma cortisol and histamine levels in the observation group after drug administration compared with before drug administration in the same group(P>0.05),while in the control group,the above indicators fluctuated significantly compared with before drug administration in the same group,and there was a significant difference between the two groups(P<0.05).The incidence of anesthesia complications was higher in the control group than in the observation group(P<0.05). Conclusion In the anesthesia regimen for patients undergoing cholecystectomy,rocuronium has a faster onset,but the efficacy of cisatracurium besilate lasts longer,but Cisatracurium besylate has a longer duration of drug efficacy,provides more stable hemodynamic conditions for patients,and offers advantages such as fewer complications and mild stress responses.
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Received: 19 May 2025
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2025, Vol. 45 
