组织学急性绒毛膜羊膜炎患者的胎膜组织病原菌分布及母婴结局分析

doi:10.3969/j.issn.1001-8131.2024.01.007

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Abstract Objective To analyze the distribution of pathogens in fetal membranes of patients with histologic acute chorioamnionitis（HAC）and the maternal and infant outcomes. Methods 8704 pregnant women were selected as the study objects,and the clinical data of mothers and infants were analyzed retrospectively.The distribution of pathogenic bacteria in fetal membrane tissue of patients with confirmed HAC and the maternal and infant outcomes were analyzed. Results Among 8704 pregnant women,614 women were diagnosed as HAC,175 women with HAC had positive pathogens by fetal membrane tissue culture,and a total of 180 strains of 26 bacteria were isolated.The distribution and number of pathogenic bacteria in women with HAC in Phase I were 24（92.31%）,159（88.33%）,and 21（11.67%）,respectively.The number of pathogenic bacteria in women with HAC in Phase I was higher than that in women with HAC in Phase Ⅱ（26.92%）.Escherichia coli was the main pathogenic bacteria in fetal membrane tissue of HAC,with a total of 107（59.44%）The second was enterococcus faecalis,18 strains（10.00%）;The incidences of premature rupture of membranes and normal delivery in HAC group were 13.52% and 7.17% lower than those in non HAC group（19.06% and 59.37%,P<0.05）,while the incidences of placental abruption,stillbirth,premature delivery,spontaneous abortion and other pregnancy outcomes in HAC group were 3.26%,2.28%,25.90%,4.40%,43.49% higher than those in non HAC group（0.57%,0.10%,9.20%,0.70%,11.00%,P<0.05）;194 pregnant women and neonates were accompanied by asphyxia or respiratory distress syndrome,51 of whom were diagnosed by HAC.The incidence of neonatal respiratory distress syndrome in HAC group was 21.57% lower than that in non HAC group（41.26%,P<0.05）,while the incidence of neonatal asphyxia was 78.43% higher than that in non HAC group（58.74%,P<0.05）. Conclusion There are 180 strains of pathogenic bacteria in the fetal membrane tissue of HAC pregnant women with 26 strains,and the number of phase I is more than that of phase Ⅱ.Escherichia coli is the main strain of HAC.HAC can increase the incidence of placental abruption,stillbirth,premature delivery,spontaneous abortion and other adverse pregnancy outcomes,as well as the incidence of postpartum neonatal asphyxia.

Key words： Histological acute chorioamnionitis Pathogen distribution Maternal and infant outcomes analysis

Received: 05 January 2023

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	Wang Lin

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Wang Lin. Distribution of Pathogenic Bacteria in Fetal Membranes of Patients with Histologic Acute Chorioamnionitis and Analysis of Maternal and Infant Outcomes[J]. journal1, 2024, 44(1): 23-26.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.01.007 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I1/23

[1] 郭蕾蕾,郭晓霞,曾慧慧.胎膜早破且胎盘组织学急性绒毛膜羊膜炎母婴临床观察[J].山西医药杂志,2021,50(24):3350-3354.
[2] 王一枭,贾瑞喆,赵亭亭,等.血浆肝素结合蛋白对足月胎膜早破伴发急性绒毛膜羊膜炎的预测效能[J].山东医药,2021,61(36):45-48.
[3] 余红波,符策岗.绒毛膜羊膜炎的临床诊断及治疗进展[J].医学研究生学报,2019,32(1):109-112.
[4] 解泽强,陈亮,张曼.2016~2017年泌尿系感染病原菌特征分析[J].标记免疫分析与临床,2018,25(5):610-615.
[5] Levy M,Mor L,Kovo M,et al.Histologic chorioamnionitis in pregnancies complicated by preeclampsia and the effect on neonatal outcomes[J].Reprod Sci,2021,28(7):2029-2035.
[6] Matulova J,Kacerovsky M,Hornychova H,et al.Acute histological chorioamnionitis and birth weight in pregnancies with preterm prelabor rupture of membranes:a retrospective cohort study[J].Front Pharmacol,2022,13:861785.
[7] Choi SR,Kim T,Kim Y,et al.The relationship between matrix metalloproteinase-8 in after birth oral fluid and acute histologic chorioamnionitis in preterm delivery[J].Reprod Sci,2021,28(7):2023-2028.
[8] 梁辉标,叶知昀,高洁,等.胎膜早破与急性绒毛膜羊膜炎的关系及绒毛膜羊膜炎致病菌群研究[J].中华医院感染学杂志,2017,27(14):3281-3284.
[9] 吴莺,王燕,段洁,等.孕34周前胎膜早破早产病例中组织学诊断绒毛膜羊膜炎与母婴结局的临床分析[J].中国妇产科临床杂志,2016,17(3):259-260.
[10] 黄亚军,张艳彬,赵艳丽,等.孕晚期血清炎症细胞因子和B族链球菌感染与绒毛膜羊膜炎和围生儿感染的相关性[J].中国妇幼保健,2021,36(14):3183-3186.
[11] 周丽,王永红.IL-1β,MMP-8和胎儿胸腺等预测胎膜早破合并绒毛膜羊膜炎的研究进展[J].国际妇产科学杂志,2019,46(1):44-47.
[12] 符春丽,唐梅,林丽慧,等.NLRP3通路相关蛋白在胎膜早破孕妇胎膜组织中的表达及其与组织学绒毛膜羊膜炎的关系[J].中华医院感染学杂志,2021,31(16):2502-2506.
[13] 李楠,白晓红,宋丽娜,等.胎膜早破孕产妇胎膜组织中NAMPT表达及其与绒毛膜羊膜炎的相关性[J].中华医院感染学杂志,2022,32(12):1825-2828.
[14] 张荣萍,何晓梅,周玲.孕34周前胎膜早破早产病例中组织学诊断绒毛膜羊膜炎与母婴结局的临床分析[J].贵州医药,2019,43(11):1734-1735.