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| Clinical Diagnostic Value of Combined Detection of Tumor Markers AFP,AFP-L3 and DCP on Primary Hepatic Carcinoma |
| Liu Yuxi |
| Department of Laboratory Medicine,Kaifeng Cancer Hospital,Kaifeng 475000,China |
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Abstract Objective To analyze the clinical value of combined detection of AFP,AFP-L3 and DCP in the diagnosis of primary hepatic carcinoma. Methods 50 patients with primary hepatic carcinoma admitted to our hospital were included in the observation group,and 50 patients with hepatitis B cirrhosis were set as the control group.All patients underwent laboratory examination,and the levels of AFP,DCP and AFP-L3 were compared,and the diagnostic efficiency was calculated,and the ROC curve area was observed. Results The AFP of the observation group was higher than that of the control group [（834.21±100.35）ug/L vs.（100.04±10.42）ug/L]（t=51.481,P<0.001）.The AFP-L3 was（14.61±6.11）% in the observation groups and was（7.00±1.21）% in the control group（t=172.078,P<0.001）. There was a statistically significant difference in the DCP between the observation group and the control group [（3016.33±122.02）mAU/ml vs.（36.73±10.11）mAU/ml]（t=8.639,P<0.001）.The sensitivity and accuracy of combined detection in diagnosing primary hepatic carcinoma were the highest at 92.00% and 86.00% respectively.And the Kappa value of disease diagnosis was 0.72,showing good diagnostic consistency.The area under the curve of combined detection was 0.930,and the areas under the curves of AFP,DCP and AFP-L3 were 0.745,0.731 and 0.709 respectively,and the area under the curve of combined detection was the largest. Conclusion In the clinical diagnosis of primary hepatic carcinoma,the single AFP,AFP-L3 and DCP diagnosis all have high sensitivity,but the combined detection of the three can improve the ability of disease identification and reduce missed diagnosis and misdiagnosis.
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Received: 01 December 2020
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2021, Vol. 41 
