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| Analysis of Related Substances in Dexamethasone Sodium Phosphate Injection |
| Liu Xiuqing |
| Heilongjiang Provincial Drug Audit and Inspection Center,Harbin 150090,China |
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Abstract Objective To investigate the determination of related substances in dexamethasone sodium phosphate injection. Methods HPLC method was used as the raw material of dexamethasone sodium phosphate and the related substances in injection and the journal were tested,and the function and relationship of dexamethasone sodium phosphate and excipients as well as the composition of the journal were analyzed. Results The solvent was mobile phase,the two components' trailing factor,theoretical plate number and separation degree were higher in methanol solvent. The solvent was mobile phase. The theoretical plate number,trailing factor and separation degree of two components were higher than that of methanol solvent. Conclusion The technological improvement,strengthening quality control and effectively perfecting test data can create good value for the safe use of Dexamethasone Sodium Injection.
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Received: 15 June 2021
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[2] 万丹,谭永红.我院地塞米松磷酸钠注射液超说明书用药分析评价[J]. 西南军医,2019,21(2):177-180.
[3] 何光照,张晓璐,王玲娜,等. 5-HT3RAs与地塞米松磷酸钠注射液在注射器中的相容性[J]. 药学与临床研究,2020,28(1):47-50.
[4] 马红,达娟,刘美玉,等.咪达唑仑预处理对地塞米松磷酸钠引起会阴部瘙痒的影响[J]. 国际麻醉学与复苏杂志,2020,41(12):1159-1162.
[5] 杨辉彬,朱国琦.地塞米松磷酸钠注射液治疗上呼吸道感染患者的常见不良反应[J]. 基层医学论坛,2019,23(17):2396-2397. |
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2022, Vol. 42 
