甲基多巴联合拉贝洛尔对子痫前期患者血流动力学及妊娠结局的影响

doi:10.3969/j.issn.1001-8131.2022.05.008

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (294 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the effect of methyldopa combined with labetalol on hemodynamics and pregnancy outcome in patients with preeclampsia. Methods 78 cases of preeclampsia were selected and divided into observation group（n=39）and control group（n=39）according to the drawing method.On the basis of conventional treatment,the control group was treated with magnesium sulfate,and on the basis of the control group,the observation group was treated with methyldopa and labetalol.The clinical efficacy,hemodynamics and pregnancy outcome were compared between the two groups. Results Compared with the control group,the clinical total effective rate of the observation group was higher（P<0.05）.After 1 week of treatment,map and peripheral resistance of the two groups were lower than those before treatment,and cardiac index was higher than that before treatment,and the observation group was better than the control group（P<0.05）.Compared with the control group,the total incidence of adverse pregnancy outcomes in the observation group was lower（P<0.05）. Conclusion The combined treatment of methyldopa and labetalol in patients with preeclampsia has definite effect,which can effectively regulate the hemodynamics of patients and improve the pregnancy outcome,which is worthy of clinical application.

Key words： Preeclampsia Labetalol Methyldopa Hemodynamics Pregnancy outcome

Received: 09 July 2021

PACS:

R714.24+5

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Guo Xiaoli

Cite this article:

Guo Xiaoli. Effect of Methyldopa Combined with Labetalol on Hemodynamics and Pregnancy Outcome in Patients with Preeclampsia[J]. journal1, 2022, 42(5): 19-21.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2022.05.008 OR http://www.hrbyybjb.org.cn/EN/Y2022/V42/I5/19

[1] Preenan P,Kogi M,Jagidesa M.Placenta-derived exosomes:potential biomarkers of preeclampsia[J].Int J Na-nomedicine,2017,11(12):8009-8023.
[2] Saghafi N,Pourali L,Ghanbarabadi VG.Serum heat shock protein 70 in preeclampsia and normal pregnancy:A systematic review and meta-analysis[J].JAMA,2018,16(1):1-8.
[3] 王晓临,肖建平.硫酸镁联合拉贝洛尔治疗早发型重度子痫前期效果观察[J].山东医药,2016,56(44):63-64.
[4] 谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:64-71.
[5] 徐红. 拉贝洛尔对早发型重度子痫前期患者子宫螺旋动脉血流动力学及胎盘微血管密度的影响观察[J].中国计划生育和妇产科,2017,9(9):41-43.
[6] 刘晓辉,李莉.拉贝洛尔联合硫酸镁对子痫前期患者血清VEGF及sFlt-1表达及妊娠结局的影响[J].湖南中医药大学学报,2016,36(2):1045-1045.
[7] 张幼林. 拉贝洛尔联合硫酸镁治疗早发型重度子痫前期的效果分析[J].实用临床医药杂志,2019,23(2):62-65.
[8] 常春玲,孙鸿,林林,等.早发型重度子痫前期患者应用拉贝洛尔治疗对母婴结局以及PT、Fg等的影响[J].检验医学与临床,2017,14(1):94-97.
[9] 陈桂林,曹永涛,秦新蕾.拉贝洛尔结合硫酸镁治疗对早发型重度子痫前期患者的疗效及对妊娠结局的影响[J].河北医药,2018,40(4):574-576.
[10] 汤莹莹,张帆.甲基多巴联合拉贝洛尔对控制子痫前期孕妇血压及血清LIF、Apelin表达的影响[J].中国计划生育学杂志,2018,26(10):37-40.
[11] 许曼,李丽贤,廖义鸿.甲基多巴及拉贝洛尔联合硫酸镁对重度早发型子痫前期患者的疗效及安全性分析[J].中国生育健康杂志,2017,28(3):237-239.
[12] 吕银凤,尉爱红,卢佳等.拉贝洛尔联合甲基多巴对妊娠期高血压疾病患者血流动力学指标及母婴妊娠结局的影响[J].解放军预防医学杂志,2018,36(11):1425-1427.