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| Effect of Insulin Aspart Combined With Metformin on Blood Glucose and Pregnancy Outcome in Patients With Gestational Diabetes Mellitus |
| Fan Lijun, Tian Li, Shi Xuemin |
| Department of Obstetrics and Gynecology,Anyang Maternal and Child Health Hospital,Anyang 455000,China |
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Abstract Objective To observe the effect of insulin aspart combined with metformin on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus（GDM）. Methods 110 GDM patients admitted to our hospital were selected to carry out research,and the patients were divided into control group（55 cases）and observation group（55 cases）according to the same proportion.The observers were treated with metformin on the basis of control.The changes of blood glucose level and pregnancy outcome of pregnant women in the two groups were compared,and the neonatal complications were compared between the two groups. Results After treatment,the levels of FPG（4.26 0.67）mmol/L,1HPG（8.11 0.23）mmol/L and 2HPG（7.41 0.38）mmol/L in the observation group were lower than those in the control group（5.12 0.87）mmol/L and（8.46）The pregnancy outcome in the observation group was better than that in the control group.The total incidence of cesarean section,polyhydramnios and macrosomia in the observation group was 12.72%,which was lower than that in the control group（30.91%,P<0.05）.The incidence of neonatal complications in the observation group was 10.91%,which was lower than that in the control group（27.27%,P<0.05）. Conclusion Insulin aspart combined with metformin is used to treat GDM,It can reduce the blood sugar,and the combination of the two drugs has better therapeutic effect,so that the blood sugar of patients can be controlled in the normal range,and the pregnancy outcome can be improved and the complications can be reduced,which can be popularized and applied.
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Received: 13 July 2021
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[1] 郭晓莉. 门冬胰岛素联合二甲双胍对妊娠期糖尿病患者血糖控制及妊娠结局的影响[J].实用糖尿病杂志,2020,16(2):64-66.
[2] 李国平,蒋丽萍,周智平,等.新诊断标准筛查妊娠期糖尿病患者的临床应用及意义[J].中国妇幼保健,2017,8(32):18-19.
[3] 高新艳. 二甲双胍联合门冬胰岛素30对妊娠期糖尿病患者血糖控制及妊娠结局的影响[J].现代诊断与治疗,2018,29(2):240-241.
[4] 陶朝慧,喻晓燕.妊娠期糖尿病患者血糖控制效果对妊娠结局的影响[J].中国妇幼保健,2017,32(7):1426-1429.
[5] 王燕,宋向欣,王新玲.诺和锐联合二甲双胍治疗妊娠期糖尿病的疗效及对妊娠结局的影响[J].中南医学科学杂志,2019,47(1):58-60. |
| [1] |
. [J]. journal1, 2022, 42(3): 129-130. |
| [2] |
. [J]. journal1, 2021, 41(6): 55-56. |
| [3] |
. [J]. journal1, 2021, 41(6): 75-76. |
| [4] |
Xie Weijia, Huang Liming, Huang Zhedan. Clinical Efficacy of Glipizide Combined With Metformin Hydrochloride in the Treatment of Elderly Diabetes[J]. journal1, 2021, 41(3): 8-9. |
| [5] |
. [J]. journal1, 2021, 41(2): 49-50. |
| [6] |
. [J]. journal1, 2021, 41(2): 61-62. |
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2022, Vol. 42 
