健脾通络汤对脾胃虚寒型Hp阳性慢性萎缩性胃炎患者血清G-17、胃蛋白酶水平及免疫功能的影响

doi:10.3969/j.issn.1001-8131.2023.02.042

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (427 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the clinical effect and safety of Jianpi Tongluo Decoction in the treatment of Helicobacter pylori（HP）- positive chronic atrophic gastritis（CAG）of spleen stomach deficiency and cold type. Methods 88 patients with HP positive CAG treated were randomly divided into control group（44 cases）and observation group（44 cases）.The control group was treated with triple therapy,and the observation group was treated with Jianpi Tongluo Decoction for 1 month.The clinical efficacy,serum gastrin-17（G-17）,pepsin level,immune function and safety were compared between the two groups. Results the total effective rate of the observation group was higher than that of the control group（P<0.05）;G-17 [（386.74 ± 38.64）ng /L] and pepsinogen Ⅰ（PG Ⅰ）[（58.13±5.33）in the observation group after treatment μg/L] was higher than that in the control group [（342.89±35.79）ng/L,（54.15±5.25）μg/L],pepsinogen Ⅱ（PG Ⅱ）[（10.35±1.53）μg/L] was lower than that in the control group [（13.68±1.71）μg/L],with statistical difference（P<0.05）;After treatment,CD4+ [（45.85±4.82）%] and CD4+/CD8+ [（1.85±0.28）] in the observation group were higher than those in the control group [（41.41±4.56）%,（1.58±0.26）],and CD8+ [（24.85±2.11）%] were lower than those in the control group [（26.23±2.27）%]（P<0.05）;There were no serious adverse reactions in both groups. Conclusion Jianpi Tongluo Decoction can improve the therapeutic effect of HP positive CAG of spleen stomach deficiency cold type,correct the abnormal immune function of patients,and accelerate the normalization of G-17,PG Ⅰ and PG Ⅱ.It is safe and reliable.

Key words： chronic atrophic gastritis Deficiency cold of spleen and stomach Jianpi Tongluo Decoction Pepsin immunity Security

Received: 07 May 2022

PACS:

R573.3+2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Li Changlu

Cite this article:

Li Changlu. Effect of Jianpi Tongluo Decoction on Serum G-17,Pepsin Level and Immune Function in Patients with HP Positive Chronic Atrophic Gastritis of Spleen Stomach Deficiency Cold Type[J]. journal1, 2023, 43(2): 114-116.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2023.02.042 OR http://www.hrbyybjb.org.cn/EN/Y2023/V43/I2/114

[1] 冯庆. 荆花胃康胶丸联合瑞巴派特治疗慢性萎缩性胃炎的临床研究[J].现代药物与临床,2021,36(5):952-956.
[2] 王静,倪建俐,王萍,等.养阴利湿方治疗慢性萎缩性胃炎的疗效及对血清胃蛋白酶原,胃泌素的影响[J].医学综述,2021,27(2):413-417.
[3] 姚鹏,康洪昌,王江,等.荜铃胃痛颗粒联合三联疗法治疗慢性萎缩性胃炎合并幽门螺杆菌感染的临床研究[J].天津中医药,2021,38(9):1138-1143.
[4] 张曼,高炳霞,齐颖,等.依卡倍特钠联合常规四联疗法对幽门螺杆菌阳性慢性萎缩性胃炎的疗效观察[J].现代消化及介入诊疗,2020,25(1):76-79.
[5] 兰青,马尚清,赵兵,等.健脾通络汤治疗慢性萎缩性胃炎伴广泛肠化脾胃虚弱证的疗效观察[J].中华中医药杂志,2019,34(8):3880-3882.
[6] 钱家鸣,历有名,林菊生,等.消化内科学[M].北京:人民卫生出版社,2014:68-79.
[7] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:189-190.
[8] 李德成,张守菊,李霞.胃炎宁颗粒联合维酶素治疗慢性萎缩性胃炎的临床研究[J].现代药物与临床,2019,34(5):1379-1383.
[9] 张紫涵,陈俊,徐丹.苦参碱联合胃复春片治疗慢性萎缩性胃炎疗效及对患者血清胃蛋白酶原亚群的影响[J].陕西中医,2021,42(3):323-325,333.
[10] 马润兴,马玉寿.自拟温胃散寒汤治疗脾胃虚寒型慢性萎缩性胃炎的临床效果[J].中国医药导报,2019,16(25):118-121.
[11] 叶骏,苗丽,郑安斌,等.摩罗丹联合奥美拉唑治疗对慢性胃炎患者疗效及炎症因子、胃蛋白酶原水平的影响[J].海军医学杂志,2020,41(5):548-551.
[12] 王国庆,刘红军,梁素芳.益气活血方联合三联疗法对气虚血瘀型慢性萎缩性胃炎患者炎性反应和血液流变学的影响[J].世界中医药,2019,14(1):182-186.