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| Effect of Salvianolate on Pulmonary Rehabilitation and Balance of Th1/Th2 Immune Response in Patients with AECOPD |
| Su Xing, Chen Gaoying, Qi Hongsong, Wang Hongyan |
| Department of respiratory and critical care medicine The First Affiliated Hospital of Henan University 457000,China |
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Abstract Objective To explore the effect of salvianolate assisted lung rehabilitation in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD）and its influence on the balance of Th1/Th2 immune response.Methods 80 patients with AECOPD were randomly divided into observation group and control group,Lung rehabilitation therapy and salvianolate assisted lung rehabilitation therapy were selected,and the balance of Th1/Th2 immune response and lung function were compared between the two groups after 2 weeks of treatment,and the improvement time of symptoms,hospitalization time,lung injury rate and mortality rate were evaluated.Results IL-4 and IFN in the observation group were significantly higher than those in the control group-γ、FEV1,FVC and fef75% in the observation group were better than those in the control group（P<0.05）,and the hospitalization time in the observation group was shorter than that in the control group（P<0.05）,The rate of ventilator-associated lung injury was lower than that of control group（P<0.05）.Conclusion The effect of salvianolate assisted lung rehabilitation in patients with AECOPD is significant,which can improve the immune function,enhance the lung function of patients,and improve the treatment effect.
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Received: 26 July 2022
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2023, Vol. 43 
