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| Clinical Efficacy and Safety Analysis of Intravenous Thrombolysis and Bridging Stent Thrombectomy in the Treatment of Acute Cerebral Infarction |
| Li Dong, Ma Chengdong, Wang Shufeng |
| Neurological intensive care unit of Sanmenxia Central Hospital Sanmenxia City,Henan Province,472000 |
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Abstract Objective To investigate the clinical efficacy and safety of intravenous thrombolysis bridging stent thrombectomy in the treatment of acute cerebral infarction.Methods 102 patients with acute cerebral infarction caused by intracranial artery occlusion were selected.The control group received intravenous thrombolysis with recombinant human tissue type plasminogen activator（trade name：alteplase）（RT PA）,while the observation group was treated with solitaire AB stent bridging on the basis of RT PA intravenous thrombolysis,The clinical effect,blood vessel recanalization and activities of daily living（ADL）,serological indexes and safety of the two groups were analyzed.Results There was no significant difference in NIHSS and Barthel scores between the two groups before treatment（P>0.05）;After treatment,the NIHSS score of the observation group was lower than that of the control group,Barthel score was higher（P<0.05）;The recanalization rate of the observation group was 70.59%,which was higher than 41.18% of the control group（P<0.05）;There was no significant difference in hs CRP,sICAM-1,IGF-1 and NSE between the two groups before treatment（P>0.05）;After treatment,the levels of hs CRP,sICAM-1 and NSE in the two groups decreased,while IGF-1 increased to a certain extent.The levels of hs CRP,sICAM-1 and NSE in the observation group were lower than those in the control group,while IGF-1 in the observation group was higher than that in the control group,The difference was statistically significant（P<0.05）;There was no significant difference in the total incidence of complications between the two groups（P>0.05）,and there was no significant difference in 90d mortality between the two groups（P>0.05）.Conclusion Compared with single intravenous thrombolytic therapy,intravenous thrombolytic bridging stent can obtain better clinical efficacy in the treatment of acute cerebral infarction,The reduction of nerve injury is conducive to the recovery of nerve function,and the inflammatory reaction is relieved.The incidence of complications and 90 day mortality is less,so it has high application value.
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Received: 09 July 2022
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[1] 周志远,赵瑞雅.Solitaire AB支架机械介入取栓术联合溶栓治疗急性脑梗死的临床效果及预后研究[J].贵州医药,2021,45(2):208-209.
[2] 胡杨真,胡列计,黄婉洁.阿替普酶静脉溶栓桥接Solitaire AB支架取栓术治疗急性脑梗死的疗效分析[J].卒中与神经疾病,2019,26(2):148-152.
[3] 熊波,李航,史树贵,等.Solitaire支架机械取栓与选择性动脉溶栓治疗急性脑梗死的疗效比较[J].局解手术学杂志,2017,26(3):185-188.
[4] 中国卒中学会.急性缺血性脑卒中血管内治疗术后监护与管理中国专家共识[J].中华医学杂志,2017,97(3):162-172.
[5] 尚淑玲,沈海涛,李迥,等.超选择性动脉溶栓联合支架取栓在治疗大动脉脑梗死患者中的应用[J].中华保健医学杂志,2020,22(3):161-163.
[6] 马骥,刘蕊.静脉溶栓桥接支架取栓治疗对急性脑梗死患者神经功能和血管再通率的影响分析[J].四川解剖学杂志,2020,28(2):62-63,75.
[7] 冯丽燕,卢晔芬,孙丽娜.静脉溶栓联合支架取栓治疗急性大脑中动脉闭塞性脑梗死的疗效观察[J].浙江临床医学,2020,22(3):414-415.
[8] 吴迎春,王俊梅,王哲,等.尿激酶静脉溶栓联合Solitaire AB支架取栓在前循环大动脉急性闭塞性脑梗死治疗中的应用研究[J].脑与神经疾病杂志,2017,25(8):497-502. |
| [1] |
. [J]. journal1, 2023, 43(4): 140-142. |
| [2] |
. [J]. journal1, 2023, 43(3): 65-66. |
| [3] |
. [J]. journal1, 2023, 43(3): 67-69. |
| [4] |
. [J]. journal1, 2023, 43(3): 123-125. |
| [5] |
. [J]. journal1, 2023, 43(2): 117-118. |
| [6] |
Ma Junbao, Li Dashan, Sun Xiaopin. Effect of Butylphthalide Combined With Shenmai Injection on Nerve and Vascular Endothelial Function in Acute Cerebral Infarction[J]. journal1, 2022, 42(6): 1-3. |
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2023, Vol. 43 
