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2021 Vol. 41, No. 1
Published: 2021-02-25
1
The Application of Serum Ca Combined With 99mTc MIBI Dual Phase Imaging in the Diagnosis of Primary Hyperparathyroidism
Xie sheng, Liu Yuanhong
Objective
To explore the application of serum Ca combined with 99mTc MIBI dual phase imaging in the diagnosis of primary hyperparathyroidism.
Methods
From 58 patients with hypercalcemia were examined.The detection rate and results of several detection methods were compared by retrospective analysis and investigation.
Results
In 58 patients,the detection rate of serum Ca combined with 99mTc MIBI dual phase imaging in the diagnosis of primary hyperparathyroidism（35 cases,60.34%） was the same as that of B-ultrasound,which was higher than that of CT（30 cases,51.72%）（
P<
0.05）;the specificity of three detection methods was 100%,and the sensitivity of CT and B-ultrasound was lower than that of serum Ca combined with 99mTc MIB The sensitivity of serum Ca combined with 99mTc MIBI dual phase imaging was 87.59%,the positive predictive value was 98.00%,the negative predictive value was 89.33%（
P<
0.05）.According to the results of several imaging methods,serum Ca combined with 99mTc MIBI dual phase imaging showed that 35 of 58 patients were diagnosed as parathyroidism,including 32 parathyroid adenomas and 2 parathyroid hyperplasia 2 cases were parathyroid cancer.By B-ultrasonic examination,35 cases were diagnosed as hyperparathyroidism,including 20 parathyroid adenomas and 2 hyperparathyroidism.In addition,38 cases were diagnosed as hyperparathyroidism by CT,of which 14 were parathyroid adenoma（
P<
0.05）.
Conclusion
In the diagnosis of primary hyperparathyroidism,serum Ca combined with 99mTc MIBI dual phase imaging is simple,easy and accurate,which can reduce the misdiagnosis and mistreatment of primary hyperparathyroidism,and it is worthy of clinical promotion.
2021 Vol. 41 (1): 1-2 [
Abstract
] (
120
)
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3
Influence of High-Dose Immunoglobulin Combined With Glucocorticoids on Peripheral blood Th17 Cell Levels in Children With Immune Thrombocytopenia
Huang Xiaolong
Objective
To investigate the effects of high-dose immunoglobulin combined with glucocorticoids on peripheral blood Th17 cell levels in children with immune thrombocytopenia（ITP）.
Methods
A total of 78 children with ITP who were admitted were enrolled.Using random number table method,they were divided into medium-dose group（routine-dose immunoglobulin and glucocorticoid,n=38） and high-dose group（high-dose immunoglobulin combined with glucocorticoid,n=40）.The clinical effects of the two groups were compared.Changes in levels of peripheral blood helper T cell 17（Th17） and regulatory T cells（Treg） before and after treatment in both groups were observed.Th17/Treg was calculated,and drug safety of the two groups was compared.
Results
The total effective rate in the high-dose group was significantly higher than that in the middle-dose group（
P<
0.05）.Compared with the same group before treatment,Th17 and Th17/Treg in the two groups after treatment were obviously decreased,while Treg was significantly increased;however,Th17 and Th17/Treg in the high-dose group after treatment were significantly lower than those in the middle-dose group,while Treg was significantly higher than that in the middle-dose group（
P<
0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups [17.50%（7/40） vs 10.53%（4/38）]（χ
2
=0.782,
P
>0.05）.
Conclusion
High dose immunoglobulin combined with glucocorticoid in the treatment of immune thrombocytopenia has a significant clinical effect and high safety,which can effectively change the content of Th17 and Treg,regulate the balance of Th17/Treg cells.
2021 Vol. 41 (1): 3-5 [
Abstract
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108
)
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6
Clinical Observation on Different Surgical Timings in the Treatment of Anklebone Fracture Disposition
Yang Peng, Su Haitao
Objective
To explore the clinical effects of different surgical timings in the treatment of anklebone fracture disposition.
Methods
Eighty patients with anklebone fracture disposition who were treated in the hospital were selected as the research subjects,and they were divided into early group and elective group according to the random number table method,with 40 cases in each group.Early group underwent emergency surgery,and elective group underwent elective surgery.The differences in surgery and recovery（operative time,hospital stay,fracture healing time） were compared between the two groups.The ankle function [Baird-Jackson Function Score Scale,American Orthopedic Foot and Ankle Society（AOFAS）] and pain level [Numerical Rating Scale（NRS）] were compared between the two groups before surgery and at 6 months after surgery.The incidence rates of complications within 1 year after surgery were compared between the two groups.
Results
The operative time,hospital stay and fracture healing time in early group were significantly lower than those in elective group（
P<
0.05）.At 6 months after surgery,the ankle function in the two groups was significantly improved compared with that before surgery,and the score in early group was higher than that in elective group at the same time point（
P<
0.05）.There was no significant difference in the pain level between the two groups（
P
>0.05）.Within 1 year after surgery,there were no significant differences in the incidence rates of complications between the two groups（P>0.05）.
Conclusion
Early surgery has shorter operative time than elective surgery,and it can promote the prognosis and recovery,and it has better effects on the ankle function recovery,and it is worthy of clinical promotion and application.
2021 Vol. 41 (1): 6-7 [
Abstract
] (
108
)
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8
Clinical Curative Effect of Laparoscopic Gastric Perforation Repair on Patients with Gastric Ulcer Perforation and Fungal Infection
Ma Peishan
Objective
To explore clinical curative effect of laparoscopic gastric perforation repair on patients with gastric ulcer perforation and fungal infection.
Methods
Fifty patients with gastric ulcer perforation who were admitted to the hospital were enrolled.They were divided into study group and control group by random number table method,25 cases in each group.The control group was given open gastric perforation repair,while study group was given laparoscopic gastric perforation repair.The clinical curative effect of the two groups was observed and compared.
Results
The total response rate of clinical treatment in study group was significantly higher than that in control group（92.0% vs 68.0%）（
P<
0.05）.The hospitalization time,operation time,gastrointestinal recovery time and first leaving bed time in study group were shorter than those in control group（
P<
0.05）.The incidence of complications in study group was significantly lower than that in control group（8.0% vs 36.0%）（
P<
0.05）.
Conclusion
The clinical curative effect of laparoscopic gastric perforation repair is significant on patients with gastric ulcer perforation and fungal infection,which can significantly shorten operation time and hospitalization time,and promote early recovery of gastrointestinal function.
2021 Vol. 41 (1): 8-9 [
Abstract
] (
98
)
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10
Application Value of Tubular Gastroesophageal Anastomosis in Radical Resection of Esophageal Cancer
Li Shuaifeng, Yao Huajian, Liu Zhigang
Objective
To investigate the value of tubular gastroesophageal anastomosis in radical resection of esophageal cancer.
Methods
A total of 102 patients with esophageal cancer who were treated were enrolled.The random number table method was used to divide them into observation group and control group,51 cases each.The control group was treated with traditional total gastroesophageal anastomosis.The observation group was treated with tubular gastroesophageal anastomosis.Compare the perioperative indicators and postoperative complication rates.
Results
After treatment,there were no cases of death in the two groups.The gastrointestinal decompression volume of the observation group was significantly lower than that of the control group（
P<
0.05）.There was no statistically significant difference in operation time,intraoperative blood loss,hospital stay,postoperative activity time,and lymph node dissection（
P
>0.05）.There was no significant difference in the incidence of complication of anastomotic stenosis,gastric emptying,and pulmonary infection between the two groups（
P
>0.05）,while the incidence of gastroesophageal reflux was significantly lower in the observation group（
P<
0.05）.
Conclusion
Tubular gastroesophageal anastomosis can significantly improve the symptoms of esophageal cancer patients,and the incidence of postoperative gastroesophageal reflux is low.
2021 Vol. 41 (1): 10-11 [
Abstract
] (
121
)
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12
The Effect of Total Hip Replacement and Hemiarthroplasty on Hip Joint Function and Lower Extremity Movement Function in the Elderly Patients with Femoral Neck Fracture After Operation
Gao Pei, Shi Xuefei
Objective
The analysis of the treatment of full hip and semi-hip replacement in elderly patients with femur and neck fractures was given to their postoperative hip function and lower limb movement.
Methods
Retrospective collection of 60 clinical cases of elderly patients with femur and neck fractures admitted，divided into control group and experimental group，each with 30 cases，depending on the mode of surgery.Among them，the control group line semi-hip replacement，the experimental group carried out full hip replacement，the two groups of treatment was compared.
Results
3 months after surgery，the hip recovery in the experimental group was better than that of the control group，and the scores of Fugl Meyer's motion function scoring method（FMA） and daily life self-care ability assessment table（ADL） were both increased，and the experimental group was higher than the control group，with a statistically significant difference（P<0.05）.
Conclusion
Full hip replacement can promote the recovery of hip function，and it can also promote the function of lower limbs，which is beneficial to improve the daily life ability of patients.
2021 Vol. 41 (1): 12-13 [
Abstract
] (
122
)
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202
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14
Study on the Relationship Between Bone Metastasis and Serum Anti-Tartrate Acid Phosphatase,PINP,β-CTX in Patients with Breast Cancer
Yang Han, Tian Qing
Objective
To study the relationship between bone metastasis and serum anti-tartrate acid phosphatase（TRACP）,PINP and β-CTX levels in breast cancer patients.
Methods
The clinical data of 120 breast cancer patients diagnosed and treated were retrospectively analyzed.They were divided into study group（occurrence,69 cases） and control group（non-occurrence,51 cases） based on whether tumor metastasis occurred.At the same time,the patients of the study group were divided into three subgroups A,B,and C using the Soloway classification standard.The TRACP,PINP,and β-CTX levels were measured in all patients,and the relationship between the three and bone metastasis was analyzed.
Results
The serum levels of TRACP,PINP and β-CTX in the study group were significantly higher than those in the control group（
P<
0.05）;the serum levels of the patients in group C were significantly higher than those in group B and group A,and those in group B were higher than group A（
P<
0.05）.Serum levels of TRACP,PINP and β-CTX were positively correlated with the degree of bone metastases in breast cancer patients（
P<
0.05）.
Conclusions
erum levels of TRACP,PINP and β-CTX are positively correlated with the degree of bone metastasis in breast cancer patients,and can provide valuable reference for the diagnosis of bone metastases in breast cancer patients.
2021 Vol. 41 (1): 14-15 [
Abstract
] (
146
)
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16
Correlation Study Between Neonatal Physiological Diarrhea and Breast Milk Fat Content
Liu Liling, Zhang Hongliang, Xue Yiming, Xin Xiaohong
Objective
To study the correlation between neonatal physiological diarrhea and breast milk fat content.
Methods
100 healthy primiparas who were delivered were selected as subjects.The fat content and blood lipid level（TG,TC）of breast milk were measured at 3~5d,14d and 30d after delivery.Investigate the occurrence of neonatal physiological diarrhea.Neonates with physiological diarrhea were seen as observation group（n=50）,and neonates without physiological diarrhea were seen as control group（n=50）.Compare the fat content of breast milk in the two groups and analyze the relationship between breast fat content and blood lipid level.
Results
The incidence of physiological diarrhea in foremilk stage neonates was 41.00%,the incidence of physiological diarrhea in transitional period neonates was 20.00%,and the incidence of physiological diarrhea in mature neonates was 18.00%.The breast milk fat content in the foremilk stage,transitional period and mature lactation of the observation group was significantly higher than that of the control group（
P<
0.05）.There was no significant difference in maternal TC and TG levels between the transitional and mature lactation（
P>
0.05）.There was no correlation between TC and TG levels in the transitional and mature lactation periods（
P>
0.05）.
Conclusion
The incidence of physiological diarrhea in neonates is gradually decreased with the increase of breast milk fat content,and it is positively correlated with TC and TG levels in colostrum.
2021 Vol. 41 (1): 16-17 [
Abstract
] (
119
)
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18
Effects of Etidronate Disodium on Bone Mineral Density and Bone Turnover Indexes in Elderly Osteoporosis Patients
Yu Kai, Li Hualong, Cheng Shenjie, Su Jianmin
Objective
To study clinical effect and value of etidronate disodium（ED） in treatment of elderly osteoporosis patients.
Methods
A total of 160 elderly osteoporosis patients who were admitted were randomly grouped according to different clinical treatment schemes,80 cases in each group.The patients treated with D-calfor were included in control group,while patients treated with ED and D-calfor were included in experimental group.BMD scores and clinical response rates in both groups were observed and validated.
Results
The data statistics showed that clinical response rates in experimental group was significantly higher than that in control group（96.25% vs 86.25%）（
P<
0.05）.After treatment,there were significant differences in BMD score between experimental group and control group[（0.48±0.03） points vs（0.46±0.02） points]（
P<
0.05）.After treatment,there were significant differences in BMD score in experimental group before and after treatment [（0.46±0.08） vs（0.48±0.03） points]（
P<
0.05）.
Conclusion
The curative effect of ED is significant on elderly osteoporosis patients.
2021 Vol. 41 (1): 18-19 [
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92
)
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20
Effects of Laparoscopic Nephron-Sparing Tumor Resection on Renal Function and Prognosis in Patients With Stage T2 Renal Cancer
Liu Lin, Sha Wen, Ji Chuanbiao, Lu Caiguang, Ma Pengde, Wu Xinwei
Objective
To observe the effects of laparoscopic nephron-sparing surgery（LNSS） on renal function and prognosis of patients with stage T2 renal cancer.
Methods
A total of 70 patients with stage T2 renal cancer treated were selected as the research subjects,and they were divided into observation group and control group according to the random number table method,with 35 cases in each group.Control group underwent open surgery,and observation group underwent LNSS.The changes of renal function indexes [urea nitrogen（BUN）,blood creatinine（SCr）] were compared between the two groups before surgery and at 7d after surgery.The surgical status（operative time,postoperative drainage tube indwelling time,postoperative hospital stay）,occurrence of complications within 7d after surgery and prognosis（recurrence rate,survival rate） at 1 year after surgery were analyzed in the two groups.
Results
At 7d after surgery,the BUN and SCr in the two groups were significantly improved compared with those before surgery,and the indexes in observation group were significantly lower than those in control group（
P<
0.05）.The operative time,postoperative drainage tube indwelling time and postoperative hospital stay in observation group were significantly lower than those in control group（
P<
0.05）.Within 7d after surgery,there were no statistically significant differences in the incidence rates of postoperative complications and the overall incidence rate（
P
>0.05）.At 1 year after surgery,there were no statistically significant differences in the recurrence rate and survival rate between the two groups（
P
>0.05）.
Conclusion
LNSS for patients with stage T2 renal cancer is beneficial to the postoperative recovery,and is beneficial to the recovery of renal function and the improvement of prognosis.
2021 Vol. 41 (1): 20-21 [
Abstract
] (
133
)
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172
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22
Changes and Significance of Serum TGF beta 1,sIL-2R and Tumor Markers Before and After Radiotherapy in Patients With Hepatocellular Carcinoma
Wang, Jing
Objective
To investigate the changes and significance of serum transforming growth factor beta 1（TGF- beta 1）,interleukin-2 receptor（sIL-2R） and various serum tumor markers before and after radiotherapy in patients with primary liver cancer.
Methods
Selection of radiotherapy in our hospital of 90 patients with primary liver cancer（HCC group） and 90 cases of normal people were selected as control group,time of collection in March 2014~September 2016,liver cancer patients were treated by three-dimensional conformal radiation therapy,detection of TGF-before and after radiotherapy in patients with liver cancer group serum beta 1,sIL-2R,golgin 73（GP73）,alpha fetoprotein（AFP）,carcinoembryonic antigen（CEA） and compared with the control group,the subgroup analysis according to different clinical effects.
Results
Liver cancer group before and after treatment,the serum TGF-,sIL-2R,GP73 beta 1,AFP and CEA levels were significantly higher than the control group,the difference was statistically significant（
P<
0.05）;liver cancer patients 5 patients withdrew from the study,after treatment,liver TGF-serum beta 1,sIL-2R,GP73,AFP,the level of CEA before treatment were significantly decreased（
P<
0.05）;90 cases of liver cancer patients,5 cases achieved CR,PR in 52 patients,20 cases of SD patients,8 PD patients;before treatment,patients in group CR+PR and group SD+PD patients serum TGF- beta 1,sIL-2R,GP73,AFP,CEA the level of the difference was statistically significant（
P
>0.05）;after treatment,the patients in the CR+PR group serum TGF- beta 1,sIL-2R,GP73,AFP and CEA were significantly lower than in group SD+PD（
P<
0.05）.
Conclusion
The levels of serum TGF-,sIL-2R,GP73,AFP,and CEA in patients with primary liver cancer were significantly higher than those of patients with primary liver cancer,and were closely related to the effect of radiotherapy.
2021 Vol. 41 (1): 22-24 [
Abstract
] (
137
)
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137
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25
Research Value of Rapid Freezing and Fine Needle Aspiration Biopsy in the Diagnosis of Thyroid Microcarcinoma
Guo Ruina, Yang Huijie, Wei Min, Li Xiushun, Zhang Yingli, Wang Ying
Objective
To observe the research value of rapid freezing and fine needle aspiration biopsy（FNA） in the diagnosis of thyroid micropapillary carcinoma.
Methods
The clinical data of 440 patients with minimal thyroid tumor（TMA） were retrospectively analyzed.The pathological examination results of paraffin sections of postoperative tissues were the "gold standard".The accuracy of FS and FNA in the differential diagnosis of benign and malignant TMA was compared.
Results
The sensitivity of FS in diagnosis of PTMC was 97.23%（316/325）,the specificity was 87.83%（101/115）,the positive predictive value was 95.76%（316/330）,and the negative predictive value was 91.82%（101 / 110）,with an accuracy of 94.77%（417/440） and a Kappa value of 0.863.The sensitivity of FNA in diagnosis of PTMC was91.38%（297/325）,the specificity was86.96%（100/115）,positive predictive value was 95.19%（297/312）,negative predictive value was 78.12%（100/128）,accuracy was 90.23%（397/440）,and Kappa value was 0.756,The accuracy is significantly lower than the intraoperative FS（χ
2
=6.552,
P
=0.010）.
Conclusions
Compared with FNA,intraoperative FS can provide more comprehensive TMA diagnostic information,which is of great significance for the diagnosis of PTMC.
2021 Vol. 41 (1): 25-26 [
Abstract
] (
114
)
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169
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27
To Explore the Clinical Value of Acetylcysteine Combined with Ambroxol in the Treatment of Acute Episode of Chronic Obstructive Pulmonary Disease in the Elderly
Wang Yijin, Qin Guoping, Xu Jiashun
Objective
To study the clinical value of acetylcysteine combined with ambroxol in the treatment of acute attack of senile chronic obstructive pulmonary disease.
Methods
56 patients were randomly divided into two groups.28 cases in the single group were treated with ambroxol and 28 cases in the combined group were treated with acetylcysteine.The therapeutic effects of the two groups were compared.
Results
the effective rate of the combined group was 96.43%,and that of the single group was 82.14%.Compared with the single group,the combined group was higher（χ
2
=5.333,
P
=0.021）.The remission time of three clinical symptoms in the combined group was earlier than that in the single group（
P<
0.05）.The cough frequency of the combined group was lower than that of the single group（
P<
0.05）,and the proportion of sputum viscosity I and III was higher than that of the single group（
P<
0.05）;there was no statistical difference between the two groups（
P<
0.05）.
Conclusion
Acetylcysteine combined with ambroxol can relieve the dyspnea and other clinical symptoms in the elderly patients with COPD.
2021 Vol. 41 (1): 27-28 [
Abstract
] (
102
)
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143
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29
Application Value of Ambulatory Electrocardiogram in the Diagnosis of Elderly Silent Myocardial Ischemia
Zhan Wen
Objective
To explore the application value of dynamic electrocardiogram in the clinical diagnosis of elderly silent myocardial ischemia（SMI）.
Methods
A total of 78 elderly patients with SMI treated were included in the study.All patients underwent routine electrocardiogram and dynamic electrocardiogram.The positive rate of SMI detected by conventional electrocardiogram and dynamic electrocardiogram was compared,and the regularity of SMI onset in patients and the day-night pattern of SMI detected by dynamic electrocardiogram were recorded.
Results
Among 78 elderly patients with SMI,the detection rate of SMI confirmed by routine electrocardiogram（47.44%） was lower than that of dynamic electrocardiogram（78.49%）,and the difference was statistically significant（
P<
0.05）.The peak period of SMI episodes in patients was 12： 00-13： 00（73 times.h）,and the intermediate periods were 8： 00-9： 00（58 times / h） and 10： 00-11： 00（39 times / h）.The trough period is 1： 00-2： 00（3 times / h）.The number of ST-segment shifts at night was less than daytime,the duration of myocardial ischemia was longer than that of daytime,the ST-segment shift was greater than that of daytime,and the heart rate was lower than that of daytime during myocardial ischemic attack.The difference was statistically significant（
P<
0.05）.
Conclusion
Compared with conventional electrocardiogram,dynamic electrocardiogram is more suitable for the diagnosis of elderly SMI,which can improve the detection rate of SMI,reflect the characteristics of the patient's condition,so that it can be treated in time,and has higher clinical application value.
2021 Vol. 41 (1): 29-30 [
Abstract
] (
103
)
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176
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31
Clinical Value of Iodine Staining Chromoendoscopy in Differential Diagnosis of Early Esophageal Cancer and Dysplasia
Liu Xiaoyan, Lei Pingyu
Objective
To explore the clinical application of iodine staining chromoendoscopy in differential diagnosis of early esophageal cancer and dysplasia.
Methods
From July 2015 to August 2019,120 patients with suspected esophageal cancer lesions were selected.All patients were examined by pathology and iodine staining,and the results of pathological examination and iodine staining were analyzed.
Results
Pathological diagnosis： 27 cases of early esophageal cancer,48 cases of chronic inflammation,45 cases of dysplasia（including mild 17 cases,moderate 19 cases,severe 9 cases）.Early esophageal cancer with iodine staining is mainly unstained,accounted for 88.89%,and mild,moderate,and severe dysplasia iodine staining is mainly light and unstained,each accounting for 88.24%,78.95%,77.78%.The total positive detection rate after iodine staining was 97.22% higher than that before iodine staining（51.39%）（
P<
0.05）.
Conclusion
Iodine staining of early esophageal cancer is mainly non-staining,dysplasia iodine staining is mainly light and non-staining,and iodine staining chromoendoscopy has obvious clinical value in the diagnosis of early esophageal cancer and dysplasia.
2021 Vol. 41 (1): 31-32 [
Abstract
] (
125
)
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(300 KB) (
211
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33
Spatial Distribution Trend Novel Coronavirus Pneumonia Epidemic in China and Analysis of Its Related Factors
Gong Wuqing, Peng Houxue, Chen Jianguo, Min Ming, Peng Shusheng, Luo Jun
Objective
To explore the correlation between the epidemic trend of COVID - 19 and the population,population density,GDP,per capita GDP,population aging ratio,public transport passenger flow,distance from the source of disease and other factors in each province and Hubei province,so as to provide scientific guidance for epidemic prevention and control.
Methods
according to the National Bureau of Statistics released the 2019 annual China provinces and cities in Hubei province GDP data and 2019 provinces population sample data,combined with the provincial and municipal health committee released COVID - 19 confirmed cases data with SPSS 20.0 software,the Spearman correlation analysis and stepwise linear multiple factors regression analysis,the number of confirmed cases of provinces and cities and population density of population,GDP,per capita GDP,the proportion of ageing,passenger traffic,the relevance of such factors as the distance from Wuhan.
Results
the number of COVID-19 infection was positively correlated with traffic network and economic vitality,but negatively correlated with geographical proximity.There is no correlation with population density,per capita GDP and aging ratio.
Conclusion
the epidemic trend of COVID - 19 was positively correlated with population,GDP and passenger volume,and negatively correlated with the distance from Wuhan.
2021 Vol. 41 (1): 33-36 [
Abstract
] (
157
)
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(1 KB)
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173
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37
Effects of Xingnaojing Injection on Cerebral Oxygen Metabolism and Serum Cytokines After Cardiopulmonary Resuscitation
Wang Hui, Ling Yun, Zhang Pei
Objective
To analyze the effects of Xingnaojing injection on cerebral oxygen metabolism and serum cytokines after cardiopulmonary resuscitation.
Methods
120 patients successfully treated with cardiopulmonary resuscitation in our hospital were randomly divided into experimental group and control group according to the random number table method,with 60 cases in each group.The two groups were given routine Western medicine therapy,and experimental group was treated with Xingnaojing injection on this basis.The cerebral oxygen metabolism indexes [jugular vein blood oxygen saturation（SjvO
2
）,cerebral oxygen uptake（ERO
2
）,arterial-internal jugular vein blood oxygen content difference（Ca-jvO
2
）] and serum cytokines[tumor necrosis factor-α（TNF-α）,interleukin-10（IL-10）,interleukin-6（IL-6）,central nervous specific protein（S-100β）]at and after 72h of cardiac pulsation recoveryand the incidence rate of systemic inflammatory response syndrome（SIRS） were compared between the two groups.
Results
After 72h of cardiac pulsation recovery,the SjvO
2
was increased in the two groups,but the index in experimental group was lower than that in control group,and the ERO
2
and Ca-jvO
2
were decreased,but the two indexes in experimental group were higher than those in control group（all
P<
0.05）.The S-100β and IL-10 were increased while the TNF-α and IL-6 were decreased in experimental group,and the S-100β,IL-10,TNF-α and IL-6 all were increased in control group,and the S-100β,TNF-α and IL-6 in experimental group were lower than those in control group while the IL-10 was higher than that in control group（all
P<
0.05）.The incidence rate of SIRS in experimental group was lower than that in control group（
P<
0.05）.
Conclusion
The application of Xingnaojing injection after cardiopulmonary resuscitation can inhibit the body’s inflammatory response and reduce cerebral tissue reperfusion injury,and it is beneficial to the prognosis of patients.
2021 Vol. 41 (1): 37-38 [
Abstract
] (
120
)
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144
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39
The Effect of Irbesartan and Benazepril on Coronary Artery Disease and Hypertension in Patients With Vascular Endothelial Function
Dong Chunfang, Zheng Shuaijun, Xu Haojie
Objective
To compare the effects of irbesartan and benazepril on coronary artery disease（CHD） with hypertension（EH） on vascular endothelial function parameters.
Methods
A total of 120 patients with CHD and EH were selected as test subjects and randomly divided into a study group and a control group of 60 cases each.The control group was treated with benazepril and the study group was treated with irbesartan.The changes of vascular endothelial function indexes（NO,ET-1） and morning blood pressure（DBP,SBP） of the two groups of patients were compared before and after 1 month of treatment,and the differences in adverse drug reactions within 1 month of treatment were analyzed.
Results
After 1 month of treatment,the levels of NO in the two groups were significantly higher than before treatment,and the study group was significantly higher than the control group in the same period（
P<
0.05）.The levels of ET-1 in the two groups were significantly lower than before treatment,and the study group was significantly lower than the control group at the same time（
P<
0.05）.In the morning,the levels of DBP and SBP in the two groups were significantly lower than before treatment（
P<
0.05）,and the levels of DBP and SBP between the two groups were not statistically significant（P>0.05）.Within 1 month of treatment,the incidence of dry cough in the study group was significantly lower than that in the control group（
P<
0.05）.There were no significant differences in other adverse drug reactions（P>0.05）.
Conclusion
Irbesartan is effective in treating CHD with EH,which is equivalent to benazepril,but irbesartan can significantly improve the level of vascular endothelial function in patients with CHD and EH,and the safety is better than benazepril,which is beneficial to the recovery of patients' prognosis.
2021 Vol. 41 (1): 39-41 [
Abstract
] (
133
)
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137
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118
Clinical Study on Xinningfang Decoction Combined With Metoprolol in Treatment of Premature Ventricular Contraction
Li Yongsheng
Objective
To study clinical curative effect of Xinningdan combined with metoprolol on premature ventricular contraction（PVC）.
Methods
A total of 70 PVC patients who were admitted to the hospital were enrolled.They were divided into study group and control group,35 cases in each group.The control group was treated with metoprolol,while study group was treated with Xinningfang Decoction combined with metoprolol.One month was defined as a course of treatment.They were treated for 3 courses.All indexes were compared between the two groups.
Results
The total response rate of clinical curative effect in study group was significantly higher than that in control group（91.43% vs 71.43%）（
P<
0.05）.Before treatment,there was no significant difference in heart rate or occurrence times of PVC between the two groups（
P
>0.05）.After treatment,heart rate of patients in study group was significantly slower than that in control group,and occurrence times of PVC was also significantly decreased（
P<
0.05）.There were 4 cases and 5 cases with adverse reactions in study group and control group,respectively（
P
>0.05）.
Conclusion
The curative effect of Xinningfang Decoction combined with metoprolol is better than that of metoprolol alone on PVC,which is of certain safety and few effect on patients.It can effectively alleviate patients' condition.
2021 Vol. 41 (1): 118-119 [
Abstract
] (
84
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127
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139
Research and Development in the Signal Pathway of Cancer Stem Cells（PI3K/AKT）
Gou Rong
Cancer stem cells is a small cells group that could avoid radiotherapy and chemotherapy and has a strong self-renewal ability,it is a crucial reason for tumorigenesis,cancer progression,drug resistance and carcinoma palindromia,would be the principal way to cure cancers. PI3K/AKT is a significant signaling pathway correlated with cell proliferation and differentiation,which reported could modulate cancer stem cells self-renewal and fight off drug resistance caused by cancer stem cells,therefore,it is necessary to find out the relationship between PI3K/AKT pathway and cancer stem cells and explore a new way to cure cancers.
2021 Vol. 41 (1): 139-141 [
Abstract
] (
146
)
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(1 KB)
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(406 KB) (
189
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